ArticleAlimentary pharmacology & therapeutics2011
Use and perceived effectiveness of non-analgesic medical therapies for chronic pancreatitis in the United States.
Article in Alimentary pharmacology & therapeutics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Reappraisal of xenobiotic-induced, oxidative stress-mediated cellular injury in chronic pancreatitis: a systematic review.World journal of gastroenterology · 2014Pooled it
- Genetics of constant and severe pain in the NAPS2 cohort of recurrent acute and chronic pancreatitis patients.The journal of pain · 2025Article
- Pancreatitis pain quality changes at year 1 follow-up, but GP130 remains a biomarker for pain.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2024Article
- Serum Biomarkers of Nociceptive and Neuropathic Pain in Chronic Pancreatitis.The journal of pain · 2023Observational
- Pancreatic exocrine insufficiency guidelines: more questions than answers!Hepatobiliary surgery and nutrition · 2023Article
- Central role of the sentinel acute pancreatitis event (SAPE) model in understanding recurrent acute pancreatitis (RAP): Implications for precision medicine.Frontiers in pediatrics · 2022Review
- Article
- Validation of Demographics, Etiology, and Risk Factors for Chronic Pancreatitis in the USA: A Report of the North American Pancreas Study (NAPS) Group.Digestive diseases and sciences · 2017Article
- Medical Management of Pain in Chronic Pancreatitis.Digestive diseases and sciences · 2017Review
- Systematic review and meta-analysis: Small intestinal bacterial overgrowth in chronic pancreatitis.United European gastroenterology journal · 2016Article
- Clinical Profile, Etiology, and Treatment of Chronic Pancreatitis in North American Women: Analysis of a Large Multicenter Cohort.Pancreas · 2016Article
- Total pancreatectomy with islet autologous transplantation: the cure for chronic pancreatitis?Clinical and translational gastroenterology · 2015Review
- Pharmacological attenuation of chronic alcoholic pancreatitis induced hypersensitivity in rats.World journal of gastroenterology · 2015Article
- Design and implementation of INSPPIRE.Journal of pediatric gastroenterology and nutrition · 2014Article
- Spectrum of use and effectiveness of endoscopic and surgical therapies for chronic pancreatitis in the United States.Pancreas · 2014Article
- Pharmacological pain management in chronic pancreatitis.World journal of gastroenterology · 2013Review
- Innovation and hard work: The 2015 George E. Palade Medal Award Lecture.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]Article
- Mechanism, assessment and management of pain in chronic pancreatitis: Recommendations of a multidisciplinary study group.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 12 institutions in 1 country.
Funding
Abstract
backgroundEffectiveness of medical therapies in chronic pancreatitis has been described in small studies of selected patients.
aimTo describe frequency and perceived effectiveness of non-analgesic medical therapies in chronic pancreatitis patients evaluated at US referral centres.
methodsUsing data on 516 chronic pancreatitis patients enrolled prospectively in the NAPS2 Study, we evaluated how often medical therapies [pancreatic enzyme replacement therapy (PERT), vitamins/antioxidants (AO), octreotide, coeliac plexus block (CPB)] were utilized and considered useful by physicians.
resultsOral PERT was commonly used (70%), more frequently in the presence of exocrine insufficiency (EI) (88% vs. 61%, P < 0.001) and pain (74% vs. 59%, P < 0.002). On multivariable analyses, predictors of PERT usage were EI (OR 5.14, 95% CI 2.87-9.18), constant (OR 3.42, 95% CI 1.93-6.04) or intermittent pain (OR 1.98, 95% CI 1.14-3.45). Efficacy of PERT was predicted only by EI (OR 2.16, 95% CI 1.36-3.42). AO were tried less often (14%) and were more effective in idiopathic and obstructive vs. alcoholic chronic pancreatitis (25% vs. 4%, P = 0.03). Other therapies were infrequently used (CPB - 5%, octreotide - 7%) with efficacy generally <50%.
conclusionsPancreatic enzyme replacement therapy is commonly utilized, but is considered useful in only subsets of chronic pancreatitis patients. Other medical therapies are used infrequently and have limited efficacy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.