ArticleJournal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie2010
Contribution of orthodontic load to inflammation-mediated periodontal destruction.
Article in Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Influence of circadian rhythm on effects induced by mechanical strain in periodontal ligament cells.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2025Article
- Inflammation and mechanical force-induced bone remodeling.Periodontology 2000 · 2024Review
- Comparative Experimental Evaluation of Orthodontic Appliances for Maxillary Arch Expansion.Journal of clinical medicine · 2024Article
- Mechanical force application and inflammation induce osteoclastogenesis by independent pathways.Clinical oral investigations · 2023Article
- Tendon-regulating and bone-setting manipulation promotes the recovery of synovial inflammation in rabbits with knee osteoarthritis via the TLR4-MyD88-NF-κB signaling pathway.Annals of translational medicine · 2023Article
- Lipopolysaccharides affect compressed periodontal ligament cells via Eph-ephrin signaling.Oral diseases · 2022Article
- Cyclic tensile strain affects the response of human periodontal ligament stromal cells to tumor necrosis factor-α.Clinical oral investigations · 2022Article
- Salivary MRP-8/14 and the presence of periodontitis-associated bacteria in children with bonded maxillary expansion treatment.Clinical oral investigations · 2021Article
- Gasdermin-d Played a Critical Role in the Cyclic Stretch-Induced Inflammatory Reaction in Human Periodontal Ligament Cells.Inflammation · 2019Article
- Regulation of somatostatin receptor 2 by proinflammatory, microbial and obesity-related signals in periodontal cells and tissues.Head & face medicine · 2019Article
- Identification of Aberrantly Expressed lncRNAs Involved in Orthodontic Force Using a Subpathway Strategy.Computational and mathematical methods in medicine · 2019Article
- Mechanical loading increases pro-inflammatory effects of nitrogen-containing bisphosphonate in human periodontal fibroblasts.Clinical oral investigations · 2018Article
- The Impact of Orthodontic Bands on the Marginal Periodontium of Maxillary First Molars: A Retrospective Cross-Sectional Radiographic Analysis.The open dentistry journal · 2018Article
- Tensile strength suppresses the osteogenesis of periodontal ligament cells in inflammatory microenvironments.Molecular medicine reports · 2017Article
- Iatrogenic Damage to the Periodontium Caused by Orthodontic Treatment Procedures: An Overview.The open dentistry journal · 2015Article
- Induction of IL-6 and MMP-8 in human periodontal fibroblasts by static tensile strain.Clinical oral investigations · 2014Article
- Biomechanical loading modulates proinflammatory and bone resorptive mediators in bacterial-stimulated PDL cells.Mediators of inflammation · 2014Article
- Regulation of visfatin by microbial and biomechanical signals in PDL cells.Clinical oral investigations · 2014Article
- Gene analysis of signal transduction factors and transcription factors in periodontal ligament cells following application of dynamic strain.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2012Article
- Osteoimmunological mechanisms involved in orthodontically and bacterially induced periodontal stress.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2012Article
Corrections and comments
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Authors and funding
8 authors.
Funding
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Abstract
aimOrthodontic malpractice as well as hyperocclusal forces can aggravate periodontitis-induced destruction of tooth-supporting tissues, but the underlying mechanisms for the co-destructive effect of biomechanical loading are yet to be elucidated. This in-vitro study was performed to investigate whether biomechanical forces modulate the response of periodontal ligament (PDL) cells to inflammation. MATERIALS AND
methodsPDL cells (from six donors) grown on BioFlex(®) plates were treated with interleukin (IL) 1β, which is increased at inflamed periodontal sites, and/or subjected to cyclic tensile strain (CTS) of low (3%) and high (20%) magnitudes for 1β and 6 d. The synthesis of proinflammatory mediators (IL1β, IL8, COX2), growth factors (IGF1, VEGF, TGFβ1), collagen type 1 (COL1) and osteogenic proteins (ALP, RUNX2) was analyzed by real-time PCR and ELISA. The wound fill rate was examined in an in-vitro wound healing assay. For statistical analyses, Student's t-test and ANOVA were applied (p<0.05).
resultsIn general, the IL1β-induced expression of proinflammatory mediators was significantly enhanced by CTS on day 1 and significantly downregulated on day 6. CTS of high magnitude significantly inhibited the IGF1 synthesis but significantly upregulated VEGF under normal and inflammatory conditions. In general, CTS also downregulated the IL1β-induced COL1, ALP, and RUNX2 expression. From day 5 on, the lowest wound fill rate was observed in cells which were simultaneously exposed to inflammatory and biomechanical signals.
conclusionThese findings suggest that orthodontic and occlusal loading may contribute to periodontal destruction in periodontally-diseased patients through downregulation of matrix and osteogenic proteins but not via augmentation of periodontal inflammation.
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