ArticleMolecular biology reports2011
Candidate genes involved in tanshinone biosynthesis in hairy roots of Salvia miltiorrhiza revealed by cDNA microarray.
Article in Molecular biology reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 54 citations in OpenAlex.
- Quantitative Trait Locus Mapping and Candidate Gene Analysis of the Contents of Three Tanshinone Components in Salvia miltiorrhiza Bunge.Biochemical genetics · 2025Article
- Comparative transcriptomics of two Salvia subg. Perovskia species contribute towards molecular background of abietane-type diterpenoid biosynthesis.Scientific reports · 2024Article
- Tanshinones: Leading the way into Lamiaceae labdane-related diterpenoid biosynthesis.Current opinion in plant biology · 2022Review
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- Review
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- smi-miR396b targeted SmGRFs, SmHDT1, and SmMYB37/4 synergistically regulates cell growth and active ingredient accumulation in Salvia miltiorrhiza hairy roots.Plant cell reports · 2020Article
- SmPPT, a 4-hydroxybenzoate polyprenyl diphosphate transferase gene involved in ubiquinone biosynthesis, confers salt tolerance in Salvia miltiorrhiza.Plant cell reports · 2019Article
- Tanshinones, Critical Pharmacological Components inFrontiers in pharmacology · 2019Review
- Comparative RNA-Sequence Transcriptome Analysis of Phenolic Acid Metabolism inInternational journal of genomics · 2017Article
- Expression profiles of genes involved in tanshinone biosynthesis of two Salvia miltiorrhiza genotypes with different tanshinone content.Journal of genetics · 2016Article
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- Functional Analysis of the Isopentenyl Diphosphate Isomerase of Salvia miltiorrhiza via Color Complementation and RNA Interference.Molecules (Basel, Switzerland) · 2015Article
- The Biosynthetic Pathways of Tanshinones and Phenolic Acids in Salvia miltiorrhiza.Molecules (Basel, Switzerland) · 2015Review
- Accumulation of astragalosides and related gene expression in different organs of Astragalus membranaceus Bge. var mongholicus (Bge.).Molecules (Basel, Switzerland) · 2014Article
- Microarray analysis of differentially expressed genes engaged in fruit development between table and wine grape.Molecular biology reports · 2014Article
- Past achievements, current status and future perspectives of studies on 3-hydroxy-3-methylglutaryl-CoA synthase (HMGS) in the mevalonate (MVA) pathway.Plant cell reports · 2014Review
- Combining metabolomics and transcriptomics to characterize tanshinone biosynthesis in Salvia miltiorrhiza.BMC genomics · 2014Article
- CYP76AH1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Transcriptome analysis of medicinal plant Salvia miltiorrhiza and identification of genes related to tanshinone biosynthesis.PloS one · 2013Article
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4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Salvia miltiorrhiza is a valuable Chinese herb (Danshen) that is widely used in traditional Chinese medicine. Diterpene quinones, known as tanshinones, are the main bioactive components of S. miltiorrhiza; however, there is only limited information regarding the molecular mechanisms underlying secondary metabolism in this plant. We used cDNA microarray analysis to identify changes in the gene expression profile at different stages of hairy root development in S. miltiorrhiza. A total of 203 genes were singled out from 4,354 cDNA clones on the microarray, and 114 unique differentially expressed cDNA clones were identified: six genes differentially expressed in 45-day hairy root compared with 30-day hairy root; 96 genes differentially expressed in 60-day hairy root compared with 30-day hairy root; and 12 genes unstably expressed at different stages. Among the 96 genes differentially expressed in 60-day hairy root compared with 30-day hairy root, a total of 57 genes were up-regulated, and 26 genes represent 29 metabolism-related enzymes. Copalyl diphosphate synthase, which catalyzes the conversion of the universal diterpenoid precursor (E,E,E)-geranylgeranyl diphosphate to copalyl diphosphate, was up-regulated 6.63 fold, and another six genes involved in tanshinone biosynthesis and eight candidate P450 genes were also differentially expressed. These data provide new insights for further identification of the enzymes involved in tanshinone biosynthesis.
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