Evidence map›Paper›PMID 21082260›Full record

SynthesisMolecular biology reports2011

Genetic polymorphisms of glutathione S-transferase M1 and bladder cancer risk: a meta-analysis of 26 studies.

RongGui Zhang, GuangYong Xu, WenJun Chen, WeiLi Zhang

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Molecular biology reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Association between glutathione S-transferase M1 null genotype and risk of gallbladder cancer: a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014
    Pooled it
  4. Quantitative assessment of the association between GSTM1 null genotype and laryngeal cancer risk.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2013
    Pooled it
  5. Pooled it
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  9. Trial
  10. Article
  11. Polymorphisms of NRF2 and NRF2 target genes in urinary bladder cancer patients.Journal of cancer research and clinical oncology · 2014
    Article
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

RongGui ZhangDepartment of Urology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, 400010, China.
GuangYong Xu
WenJun Chen
WeiLi Zhang

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Studies investigating the association between glutathione S-transferase M1 (GSTM1) polymorphism and bladder cancer risk report conflicting results. The objective of this study was to quantitatively summarize the evidence for such a relationship. We performed a systematic search of the National Library of Medline and Embase databases. This meta-analysis included 26 case-control studies, which included 5029 bladder cancer cases and 6680 controls. The combined results based on all studies showed that the GSTM1 null genotype was associated with an increased risk of bladder cancer (OR=1.46, 95% confidence interval [CI]=1.35, 1.57). When stratifying for race, results were similar among Asians (OR=1.60, 95% CI=1.27, 2.01) and Caucasians (OR=1.44, 95% CI=1.33, 1.57) except Africans (OR=1.25, 95% CI=0.76, 2.06). When stratifying by the smoking, stage, grade, and histological type of bladder cancer, we found no statistical association. Our meta-analysis suggests that the GSTM1 null genotype is associated with a modest increase in the risk of bladder cancer.

Indexed as

Asian PeopleBlack PeopleFemaleGenetic Predisposition to DiseaseGlutathione TransferaseHumansMaleOdds RatioPolymorphism, GeneticUrinary Bladder NeoplasmsWhite PeopleGlutathione Transferase

Identifiers

PMID21082260

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.