ArticleMolecular biology reports2011
Novel SNPs in HSP70A1A gene and the association of polymorphisms with thermo tolerance traits and tissue specific expression in Chinese Holstein cattle.
Article in Molecular biology reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 63 citations in OpenAlex.
- Intensity of estrus expression - valuable obvious determinant of fertility inAnimal biotechnology · 2023Article
- Heat Stress: A Serious Disruptor of the Reproductive Physiology of Dairy Cows.Animals : an open access journal from MDPI · 2023Review
- Heterozygous Single-Nucleotide Polymorphism Genotypes at Heat Shock Protein 70 Gene Potentially Influence Thermo-Tolerance Among Four Zebu Breeds of Nigeria.Frontiers in genetics · 2021Article
- Characterizing binding sites of heat responsive microRNAs and their expression pattern in heat stressed PBMCs of native cattle, exotic cattle and riverine buffaloes.Molecular biology reports · 2019Article
- Genetic profiling of Hsp70 gene in Murrah buffalo (Bubalus bubalis) under sub-tropical climate of India.Cell stress & chaperones · 2019Article
- Prediction models, assessment methodologies and biotechnological tools to quantify heat stress response in ruminant livestock.International journal of biometeorology · 2019Review
- A Missense Mutation of theAnimals : an open access journal from MDPI · 2019Article
- Detection of functional polymorphisms in the hsp70 gene and association with cold stress response in Inner-Mongolia Sanhe cattle.Cell stress & chaperones · 2019Article
- Characterization of miRNA profiles in the mammary tissue of dairy cattle in response to heat stress.BMC genomics · 2018Article
- Transcriptome analysis and identification of significantly differentially expressed genes in Holstein calves subjected to severe thermal stress.International journal of biometeorology · 2017Article
- Characterization of genes and pathways that respond to heat stress in Holstein calves through transcriptome analysis.Cell stress & chaperones · 2017Article
- Novel SNP identification in exon 3 of HSP90AA1 gene and their association with heat tolerance traits in Karan Fries (Bos taurus × Bos indicus) cows under tropical climatic condition.Tropical animal health and production · 2016Article
- Impact of heat stress on health and performance of dairy animals: A review.Veterinary world · 2016Review
- Effect of heat shock protein 70 polymorphism on thermotolerance in Tharparkar cattle.Veterinary world · 2016Article
- Novel SNPs in HSPB8 gene and their association with heat tolerance traits in Sahiwal indigenous cattle.Tropical animal health and production · 2016Article
- Genetic polymorphisms within exon 3 of heat shock protein 90AA1 gene and its association with heat tolerance traits in Sahiwal cows.Veterinary world · 2015Article
- Association of ATP1A1 gene polymorphism with thermotolerance in Tharparkar and Vrindavani cattle.Veterinary world · 2015Article
- Study on genetic variations of PPARα gene and its effects on thermal tolerance in Chinese Holstein.Molecular biology reports · 2014Article
- Association analysis of HSP70A1A haplotypes with heat tolerance in Chinese Holstein cattle.Cell stress & chaperones · 2013Article
- Genetic variations of HSBP1 gene and its effect on thermal performance traits in Chinese Holstein cattle.Molecular biology reports · 2013Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heat stress induces heat shock proteins (HSPs) expression and HSP70 family is one of them that have been reported to involve in cellular protection against heat stress. But whether there is any association of genetic variation in the HSP70A1A gene with thermo tolerance is unknown. PCR-SSCP and DNA sequencing were used to detect possible SNPs in HSP70A1A gene in 890 Chinese Holstein cattle. Three fragments were amplified and five novel mutations were found in HSP70A1A gene in Chinese Holstein cattle. G/A mutation was found at nucleotide 1524 in coding region that resulting two genotypes of AA and AB. T/C mutation was found at nucleotide 3494 in 3'-UTR resulting three genotypes of CC, CD and DD. The other three point mutations, G/C at nucleotide 6400, C/T at nucleotide 6600 and G/A at nucleotide 6601 were also found in 3'-UTR resulting six genotypes of EE, EF, FF, EG, FG and GG. Linkage disequilibrium (LD) analysis showed that the nucleotide 6400, 6600 and 6601 were in strong LD (D>0.75). Association analysis indicated that AB, DD and FF genotype were the thermo tolerance genotype. SBYE Green I was used to quantify HSP70A1A mRNA expression in different tissues through quantitative real-time PCR assay. The results of the real-time PCR showed that the expression of HSP70A1A mRNA in the heart was significantly higher than that in the other tissues (P<0.05). We presume that these mutations could be used in marker assisted selection for anti-heat stress cows in our breeding program.
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