SynthesisJournal of clinical immunology2011
The -308 G/A polymorphism in TNF-α gene is associated with asthma risk: an update by meta-analysis.
Synthesis in Journal of clinical immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- The association between gene polymorphisms and risk of nasopharyngeal carcinoma.Medical oncology (Northwood, London, England) · 2015Pooled it
- Association between tumor necrosis factor-α rs1800629 polymorphism and risk of asthma: a meta-analysis.PloS one · 2014Pooled it
- Polymorphisms in the CTLA-4 gene and rheumatoid arthritis susceptibility: a meta-analysis.Journal of clinical immunology · 2012Pooled it
- Biogenesis of TNF-α-insights into proteostasis and inflammation.The FEBS journal · 2026Review
- Association between inflammatory cytokine gene polymorphisms and asthma susceptibility in Chinese Han children: a retrospective case-control study for potential diagnostic biomarkers.American journal of translational research · 2026Article
- Polymorphisms of tumor necrosis factor-α, transforming growth factor-β, and interleukin-10 in asthma associated with olive pollen sensitization.Journal of immunology research · 2014Article
- TNF gene polymorphisms in cystic fibrosis patients: contribution to the disease progression.Journal of translational medicine · 2013Article
- The preventive effect of Brassica napus L. oil on pathophysiological changes of respiratory system in experimental asthmatic rat.Avicenna journal of phytomedicine · 2013Article
- Topical Review: The Emerging Field of Epigenetics: Informing Models of Pediatric Trauma and Physical Health.Journal of pediatric psychologyReview
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe -308 G/A polymorphism in TNF-α gene has been extensively investigated for association to asthma; however, results of different studies have been inconsistent. The aim of this study is to comprehensively evaluate the genetic risk of -308 G/A polymorphism in TNF-α gene for asthma.
methodsA meta-analysis was carried out to analyze the association between the -308 G/A polymorphism TNF-α gene and asthma risk.
resultsA total of 4717 cases and 5012 controls in 29 case-control studies were included in this meta-analysis. The result indicated that the variant A allele carriers had a 38% increased risk of asthma, when compared with the homozygote GG (odds ratio (OR) = 1.40, 95% confidence interval (CI), 1.13-1.68 for AA + AG vs. GG). In the subgroup analysis by ethnicity, significant elevated risks were associated with A allele carriers in Asians (OR = 1.53, 95% CI = 1.17-2.01 and P = 0.002) but not in Caucasians(OR = 1.06, 95% CI = 0.75-1.50 and P = 0.73). In the subgroup analysis by age, significant elevated risks were associated with A allele carriers in adults (OR = 1.44, 95% CI = 1.14-1.81, and P = 0.002) and children (OR = 1.37, 95% CI = 1.03-1.82, and P = 0.003). In the subgroup analysis by atopic status, significant elevated risks of asthma were associated with A allele carriers in atopic population (OR = 1.68, 95% CI = 1.34-2.10, and P < 0.00001) but not in non-atopic population (OR = 0.98, 95% CI = 0.58-1.68, and P = 0.95).
conclusionsOur results suggest that the TNF-α -308 G/A polymorphism contributes to susceptibility to asthma.
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