ArticleJournal of clinical immunology2011
CTLA-4, position 49 A/G polymorphism associated with coronary artery lesions in Kawasaki disease.
Article in Journal of clinical immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Association of PECAM-1 Gene Polymorphisms with Kawasaki Disease in Chinese Children.Disease markers · 2017Article
- Association of genetic polymorphisms with osteosarcoma risk: a meta-analysis.International journal of clinical and experimental medicine · 2015Review
- Common carotid artery intima-media thickness is useful for diagnosis of the acute stage of Kawasaki disease.BMC pediatrics · 2014Article
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- Understanding the pathogenesis of Kawasaki disease by network and pathway analysis.Computational and mathematical methods in medicine · 2013Review
- Increased risk of atopic dermatitis in preschool children with kawasaki disease: a population-based study in taiwan.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Polymorphic sites at the immunoregulatory CTLA-4 gene are associated with chronic chagas disease and its clinical manifestations.PloS one · 2013Article
- Comparison of the laboratory data between Kawasaki disease and enterovirus after intravenous immunoglobulin treatment.Pediatric cardiology · 2012Article
- Sonographic gallbladder abnormality is associated with intravenous immunoglobulin resistance in Kawasaki disease.TheScientificWorldJournal · 2012Article
- CD40 Gene polymorphisms associated with susceptibility and coronary artery lesions of Kawasaki disease in the Taiwanese population.TheScientificWorldJournal · 2012Article
- Genetic polymorphisms in Kawasaki disease.Acta pharmacologica Sinica · 2011Review
- ITPKC single nucleotide polymorphism associated with the Kawasaki disease in a Taiwanese population.PloS one · 2011Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveKawasaki disease (KD) is a systemic vasculitis of unknown etiology and primarily affects children less than 5 years of age. Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) has been suggested as a candidate gene for conferring susceptibility to autoimmunity. This study examined the correlation of CTLA-4 gene polymorphisms in KD with and without coronary artery lesions (CAL). MATERIALS AND
methodsA total of 233 KD patients and 644 controls were subjected to determination of CTLA-4 polymorphisms at (-318) C/T and (+49) A/G positions by restriction fragment length polymorphism. Susceptibility, CAL, and intravenous immunoglobulin treatment response of KD were then analyzed with genetic variants.
resultsPolymorphisms of CTLA-4 (+49 A/G) and (-318 C/T) were not significantly different between normal children and patients with KD. The CTLA-4 (+49) A allele (AA+AG genotype), however, was significantly associated with CAL formation, especially in female patients.
conclusionsThis study provides the first evidence supporting the association of CTLA-4 (+49) A/G polymorphism with the CAL formation of KD particularly in female patients.
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