ArticlePediatric cardiology2011
Disturbance of glucose homeostasis after pediatric cardiac surgery.
Article in Pediatric cardiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Prevalence of dysglycemia following paediatric cardiac surgery: a systematic review and meta-analysis.BMJ paediatrics open · 2026Pooled it
- Does a reduced glucose intake prevent hyperglycemia in children early after cardiac surgery? a randomized controlled crossover study.Critical care (London, England) · 2012Trial
- Glucose Metabolism and Stress Hyperglycemia in Critically Ill Children.Indian journal of pediatrics · 2023Review
- Prevalence and Prognostic Factors of Stress Hyperglycemia in a Pediatric Population with Acute Illness in Greece-A Prospective Observational Study.Journal of clinical medicine · 2022Article
- Effect of hyperglycemia treatment on complications rate after pediatric cardiac surgery.Journal of cardiovascular and thoracic research · 2022Article
- Stress Hyperglycemia in Children and Adolescents as a Prognostic Indicator for the Development of Type 1 Diabetes Mellitus.Frontiers in pediatrics · 2021Review
- Metabolomic Fingerprinting of Infants Undergoing Cardiopulmonary Bypass: Changes in Metabolic Pathways and Association With Mortality and Cardiac Intensive Care Unit Length of Stay.Journal of the American Heart Association · 2018Article
- Assessment of clinical outcome of children with sepsis outside the intensive care unit.European journal of pediatrics · 2018Article
- Perioperative hyperglycemia is associated with postoperative neurocognitive disorders after cardiac surgery.Neuropsychiatric disease and treatment · 2014Article
- Does tight glycemic control improve outcomes in pediatric patients undergoing surgery and/or those with critical illness?International journal of general medicine · 2013Review
- Factors associated with hyperglycemia and low insulin levels in children undergoing cardiac surgery with cardiopulmonary bypass who received a single high dose of methylprednisolone.Clinics (Sao Paulo, Brazil) · 2013Article
- Postoperative outcome for hyperglycemic pediatric cardiac surgery patients.Pediatric cardiology · 2012Article
- Stress hyperglycemia in pediatric critical illness: the intensive care unit adds to the stress!Journal of diabetes science and technology · 2012Review
- Association of hyperglycemia, glucocorticoids, and insulin use with morbidity and mortality in the pediatric intensive care unit.Journal of diabetes science and technology · 2012Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to evaluate the time course of perioperative blood glucose levels of children undergoing cardiac surgery for congenital heart disease in relation to endogenous stress hormones, inflammatory mediators, and exogenous factors such as caloric intake and glucocorticoid use. The study prospectively included 49 children undergoing cardiac surgery. Blood glucose levels, hormonal alterations, and inflammatory responses were investigated before and at the end of surgery, then 12 and 24 h afterward. In general, blood glucose levels were highest at the end of surgery. Hyperglycemia, defined as a glucose level higher than 8.3 mmol/l (>150 mg/dl) was present in 52% of the children at the end of surgery. Spontaneous normalization of blood glucose occurred in 94% of the children within 24 h. During surgery, glucocorticoids were administered to 65% of the children, and this was the main factor associated with hyperglycemia at the end of surgery (determined by univariate analysis of variance). Hyperglycemia disappeared spontaneously without insulin therapy after 12-24 h for the majority of the children. Postoperative morbidity was low in the study group, so the presumed positive effects of glucocorticoids seemed to outweigh the adverse effects of iatrogenic hyperglycemia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.