ArticleJournal of molecular evolution2011
Evolution of the relaxin/insulin-like gene family in placental mammals: implications for its early evolution.
Article in Journal of molecular evolution, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Comparative Genomic Characterization of Relaxin Peptide Family in Cattle and Buffalo.BioMed research international · 2022Article
- Secretory products of the corpus luteum and preeclampsia.Human reproduction update · 2021Review
- Evolution of the vertebrate insulin receptor substrate (Irs) gene family.BMC evolutionary biology · 2017Article
- Mechanism for insulin-like peptide 5 distinguishing the homologous relaxin family peptide receptor 3 and 4.Scientific reports · 2016Article
- Transcriptomic identification of starfish neuropeptide precursors yields new insights into neuropeptide evolution.Open biology · 2016Article
- Evolution of the relaxin/insulin-like gene family in anthropoid primates.Genome biology and evolution · 2014Article
- Vascular Endothelial Growth Factor Receptor Family in Ascidians, Halocynthia roretzi (Sea Squirt). Its High Expression in Circulatory System-Containing Tissues.International journal of molecular sciences · 2013Article
- INSL4 pseudogenes help define the relaxin family repertoire in the common ancestor of placental mammals.Journal of molecular evolution · 2012Article
- Gene duplication and positive selection explains unusual physiological roles of the relaxin gene in the European rabbit.Journal of molecular evolution · 2012Article
- New insights into ligand-receptor pairing and coevolution of relaxin family peptides and their receptors in teleosts.International journal of evolutionary biology · 2012Article
- Article
- Comparative endocrinology of aging and longevity regulation.Frontiers in endocrinology · 2011Article
- Placental contribution to the endocrinology of gestation and parturition.Animal reproductionArticle
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relaxin (RLN) and insulin-like (INSL) gene family is a group of genes involved in a variety of physiological roles that includes bone formation, testicular descent, trophoblast development, and cell differentiation. This family appears to have expanded in vertebrates relative to non-vertebrate chordates, but the relative contribution of whole genome duplications (WGDs) and tandem duplications to the observed diversity of genes is still an open question. Results from our comparative analyses favor a model of divergence post vertebrate WGDs in which a single-copy progenitor found in the last common ancestor of vertebrates experienced two rounds of WGDs before the functional differentiation that gave rise to the RLN and INSL genes. One of the resulting paralogs was subsequently lost, resulting in three proto-RLN/INSL genes on three separate chromosomes. Subsequent rounds of tandem gene duplication and divergence originated the set of paralogs found on a given cluster in extant vertebrates. Our study supports the hypothesis that differentiation of the RLN and INSL genes took place independently in each RLN/INSL cluster after the two WGDs during the evolutionary history of vertebrates. In addition, we show that INSL4 represents a relatively old gene that has been apparently lost independently in all Euarchontoglires other than apes and Old World monkeys, and that RLN2 derives from an ape-specific duplication.
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