ArticleCirculation. Cardiovascular quality and outcomes2010
Variation in recovery: Role of gender on outcomes of young AMI patients (VIRGO) study design.
Article in Circulation. Cardiovascular quality and outcomes, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
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Who cites it
70 citing papers in PubMed.
- Whole-Genome Sequencing to Characterize Monogenic and Polygenic Contributions in Patients Hospitalized With Early-Onset Myocardial Infarction.Circulation · 2019Trial
- Trial
- Gender differences in pre-event health status of young patients with acute myocardial infarction: A VIRGO study analysis.European heart journal. Acute cardiovascular care · 2016Trial
- Trial
- The China Patient-Centered Evaluative Assessment of Cardiac Events (China PEACE) retrospective study of acute myocardial infarction: study design.Circulation. Cardiovascular quality and outcomes · 2013Trial
- Myocardial Infarction Without Obstructive Coronary Disease in Later Life: Insights from the Malmö Diet and Cancer Study.Journal of clinical medicine · 2026Article
- Global, regional, and national burden of ischemic heart disease in young and middle-aged population from 1990 to 2021.Scientific reports · 2025Article
- Clinical characteristics and prognosis of myocardial infarction with nonobstructive coronary arteries evaluated by optical coherence tomography.Scientific reports · 2025Article
- Short-Term Associations Between Ambient Ozone and Acute Myocardial Infarction Onset Among Younger Patients: Results From the VIRGO Study.GeoHealth · 2025Article
- Article
- Gender-Related Factors Associated With Outcomes of Acute Coronary Syndrome in Young Female Patients.CJC open · 2024Review
- Association of marital/partner status with hospital readmission among young adults with acute myocardial infarction.PloS one · 2024Article
- Sex-Specific Associations of Obstructive Sleep Apnea Risk With Patient Characteristics and Functional Outcomes After Acute Myocardial Infarction: Evidence From the VIRGO Study.Journal of the American Heart Association · 2023Article
- Symptom Presentation among Women with Suspected Ischemia and No Obstructive Coronary Artery Disease (INOCA).Journal of clinical medicine · 2023Article
- Impact of Marital Stress on 1-Year Health Outcomes Among Young Adults With Acute Myocardial Infarction.Journal of the American Heart Association · 2023Observational
- Impact of Sex- and Gender-Related Factors on Length of Stay Following Non-ST-Segment-Elevation Myocardial Infarction: A Multicountry Analysis.Journal of the American Heart Association · 2023Observational
- Sex Differences in Symptom Complexity and Door-to-Balloon Time in Patients With ST-Elevation Myocardial Infarction.The American journal of cardiology · 2023Article
- Young Women With Acute Myocardial Infarction: Risk Prediction Model for 1-Year Hospital Readmission.CJC open · 2023Article
- Association of Sociodemographic Characteristics With 1-Year Hospital Readmission Among Adults Aged 18 to 55 Years With Acute Myocardial Infarction.JAMA network open · 2023Observational
- Gene Sequencing Identifies Perturbation in Nitric Oxide Signaling as a Nonlipid Molecular Subtype of Coronary Artery Disease.Circulation. Genomic and precision medicine · 2022Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundAmong individuals with ischemic heart disease, young women with an acute myocardial infarction (AMI) represent an extreme phenotype associated with an excess mortality risk. Although women younger than 55 years of age account for less than 5% of hospitalized AMI events, almost 16 000 deaths are reported annually in this group, making heart disease a leading killer of young women. Despite a higher risk of mortality compared with similarly aged men, young women have been the subject of few studies. METHODS AND
resultsVariation in Recovery: Role of Gender on Outcomes of Young AMI Patients (VIRGO) is a large, observational study of the presentation, treatment, and outcomes of young women and men with AMI. VIRGO will enroll 2000 women, 18 to 55 years of age, with AMI and a comparison cohort of 1000 men with AMI from more than 100 participating hospitals. The aims of the study are to determine sex differences in the distribution and prognostic importance of biological, demographic, clinical, and psychosocial risk factors; to determine whether there are sex differences in the quality of care received by young AMI patients; and to determine how these factors contribute to sex differences in outcomes (including mortality, hospitalization, and health status). Blood serum and DNA for consenting participants will be stored for future studies.
conclusionsVIRGO will seek to identify novel and prognostic factors that contribute to outcomes in this young AMI population. Results from the study will be used to develop clinically useful risk-stratification models for young AMI patients, explain sex differences in outcomes, and identify targets for intervention.
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