ArticleJournal of clinical pathology2011
High-density tissue microarrays from prostate needle biopsies.
Article in Journal of clinical pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Ki67 Is an Independent Predictor of Recurrence in the Largest Randomized Trial of 3 Radiation Fractionation Schedules in Localized Prostate Cancer.International journal of radiation oncology, biology, physics · 2018Trial
- A Simplified Method of Manually Constructing Small Format Tissue Microarray for Use in Resource-Constrained Settings.Iranian journal of pathology · 2023Article
- Methodology for tissue sample collection within a translational sub-study of the CHHiP trial (CRUK/06/016), a large randomised phase III trial in localised prostate cancer.Clinical and translational radiation oncology · 2018Article
- Genomic and Histopathological Tissue Biomarkers That Predict Radiotherapy Response in Localised Prostate Cancer.BioMed research international · 2015Review
- Overview on Techniques to Construct Tissue Arrays with Special Emphasis on Tissue Microarrays.Microarrays (Basel, Switzerland) · 2014Review
- Prognostic value of Ki-67 for prostate cancer death in a conservatively managed cohort.British journal of cancer · 2013Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundFormalin-fixed prostate biopsies are frequently the only tissue collected at the time of prostate cancer diagnosis. There is therefore a requirement for techniques that allow the use of these prostate biopsy specimens in a high-throughput analysis of immunohistochemical and fluorescence-in-situ-hybridisation-detected biomarkers.
methodsThe authors have previously described methods that allow tissue microarray (TMA) construction from prostate biopsies. Here, we describe significant technical innovations that provide an easier and more robust system of biopsy-TMA construction. RESULTS AND DISCUSSION: The TMAs produced are of a high density (up to 104 cores each, 8 × 13) and allow a multiplex analysis of biomarkers in the context of clinical trials.
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Registered trials
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