Evidence map›Paper›PMID 21081302›Full record

ReviewEnvironmental health perspectives2011

Developmental neurotoxicants in e-waste: an emerging health concern.

Aimin Chen, Kim N Dietrich, Xia Huo, Shuk-mei Ho

Open access · diamondAbstract readReview
In one paragraph

Review in Environmental health perspectives, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 3 pooled it
24.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 3 syntheses or guidelines pooled it, 350 citations in OpenAlex.

  1. Pooled it
  2. Status of electronic waste recycling techniques: a review.Environmental science and pollution research international · 2018
    Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. Review
  7. Review
  8. Analysis of the correlation between PMScientific reports · 2025
    Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Metals extraction processes from electronic waste: constraints and opportunities.Environmental science and pollution research international · 2022
    Review
  16. Article
  17. Article
  18. In Vivo Sex-Dependent Effects of Perinatal PbAdvances in experimental medicine and biology · 2022
    Article
  19. Electronic waste pollution and the COVID-19 pandemic.Environmental chemistry letters · 2022
    Article
  20. Article

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Aimin ChenDepartment of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA. aimin.chen@uc.edu
Kim N Dietrich
Xia Huo
Shuk-mei Ho
University of Cincinnati Medical Center · USShantou University · CN

Funding

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY RESEARCHP30ES006096 · NIEHS · UNIVERSITY OF CINCINNATI · PI YADAV, JAGJIT S · 1992 to 2022
$35.4M
Human developmental toxicity of metal mixture exposure from e-waste recyclingRC4ES019755 · NIEHS · UNIVERSITY OF CINCINNATI · PI CHEN, AIMIN · 2010 to 2010
$1.7M
NIEHS NIH HHS P30 ES006096NIEHS NIH HHS P30-ES006096NIEHS NIH HHS RC4 ES019755NIEHS NIH HHS RC4ES019755
6 · The paper itself

Abstract

objectiveElectronic waste (e-waste) has been an emerging environmental health issue in both developed and developing countries, but its current management practice may result in unintended developmental neurotoxicity in vulnerable populations. To provide updated information about the scope of the issue, presence of known and suspected neurotoxicants, toxicologic mechanisms, and current data gaps, we conducted this literature review. DATA SOURCES: We reviewed original articles and review papers in PubMed and Web of Science regarding e-waste toxicants and their potential developmental neurotoxicity. We also searched published reports of intergovernmental and governmental agencies and nongovernmental organizations on e-waste production and management practice. DATA EXTRACTION: We focused on the potential exposure to e-waste toxicants in vulnerable populations-that is, pregnant women and developing children-and neurodevelopmental outcomes. In addition, we summarize experimental evidence of developmental neurotoxicity and mechanisms. DATA SYNTHESIS: In developing countries where most informal and primitive e-waste recycling occurs, environmental exposure to lead, cadmium, chromium, polybrominated diphenyl ethers, polychlorinated biphenyls, and polycyclic aromatic hydrocarbons is prevalent at high concentrations in pregnant women and young children. Developmental neurotoxicity is a serious concern in these regions, but human studies of adverse effects and potential mechanisms are scarce. The unprecedented mixture of exposure to heavy metals and persistent organic pollutants warrants further studies and necessitates effective pollution control measures.

conclusionsPregnant women and young children living close to informal e-waste recycling sites are at risk of possible perturbations of fetus and child neurodevelopment.

Indexed as

AdultChildElectronic WasteEnvironmental ExposureEnvironmental PollutionHalogenated Diphenyl EthersHazardous SubstancesHumansMetals, HeavyNervous SystemPolychlorinated BiphenylsPolycyclic Aromatic HydrocarbonsRisk AssessmentHalogenated Diphenyl EthersHazardous SubstancesMetals, HeavyPolychlorinated BiphenylsPolycyclic Aromatic Hydrocarbons

Identifiers

PMID21081302
PMCPMC3080922
OpenAlexW1974288475

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.