Evidence map›Paper›PMID 21081166›Full record

ArticleJournal of structural biology2011

Possible role of DMP1 in dentin mineralization.

Elia Beniash, Atul S Deshpande, Ping An Fang, Nicholas S Lieb, Xiaoyuan Zhang, Charles S Sfeir

Open access · greenAbstract read
In one paragraph

Article in Journal of structural biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 59 citations in OpenAlex.

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  10. Self-assembly peptide PJournal of dentistry · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Elia BeniashDepartment of Oral Biology, Center for Craniofacial Regeneration, University of Pittsburgh, School of Dental Medicine, Pittsburgh, PA, USA.
Atul S Deshpande
Ping An Fang
Nicholas S Lieb
Xiaoyuan Zhang
Charles S Sfeir
University of Pittsburgh · US

Funding

Formation of the Enamel-Dentin InterfaceR01DE016703 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BENIASH, ELIA · 2006 to 2010
$1.4M
DENTIN BIOMINERALIZATIONR01DE016123 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SFEIR, CHARLES · 2004 to 2007
$1.2M
Formation of the Enamel-Dentin InterfaceR56DE016703 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BENIASH, ELIA · 2012 to 2012
$370k
NIDCR NIH HHS DE16703NIDCR NIH HHS R01 DE016123NIDCR NIH HHS R01DE016123NIDCR NIH HHS R01 DE016703NIDCR NIH HHS R56 DE016703
6 · The paper itself

Abstract

Dentin Matrix Protein 1 (DMP1), the essential noncollagenous proteins in dentin and bone, is believed to play an important role in the mineralization of these tissues, although the mechanisms of its action are not fully understood. To gain insight into DMP1 functions in dentin mineralization we have performed immunomapping of DMP1 in fully mineralized rat incisors and in vitro calcium phosphate mineralization experiments in the presence of DMP1. DMP1 immunofluorescene was localized in peritubular dentin (PTD) and along the dentin-enamel boundary. In vitro phosphorylated DMP1 induced the formation of parallel arrays of crystallites with their c-axes co-aligned. Such crystalline arrangement is a hallmark of mineralized collagen fibrils of bone and dentin. Interestingly, in DMP1-rich PTD, which lacks collagen fibrils, the crystals are organized in a similar manner. Based on our findings we hypothesize, that in vivo DMP1 controls the mineral organization outside of the collagen fibrils and plays a major role in the mineralization of PTD.

Indexed as

AnimalsCell LineDentinExtracellular Matrix ProteinsImmunohistochemistryIncisorMiceMicroscopy, Electron, TransmissionPhosphoproteinsPhosphorylationRatsRats, WistarDmp1 protein, mouseDmp1 protein, ratExtracellular Matrix ProteinsPhosphoproteins

Identifiers

PMID21081166
PMCPMC3073716
OpenAlexW2073126832

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.