ArticleBiophysical journal2010
A stochastic model for chemotaxis based on the ordered extension of pseudopods.
Article in Biophysical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Dynamic cluster field modeling of collective chemotaxis.Scientific reports · 2024Article
- Three-component contour dynamics model to simulate and analyze amoeboid cell motility in two dimensions.PloS one · 2024Article
- Pseudopod Tracking and Statistics During Cell Movement in Buffer and Chemotaxis.Methods in molecular biology (Clifton, N.J.) · 2024Article
- ZnO-based micromotors fueled by CONational science review · 2021Article
- On the Three-Dimensional Correlation Between Myofibroblast Shape and Contraction.Journal of biomechanical engineering · 2021Article
- Short- and long-term memory of moving amoeboid cells.PloS one · 2021Article
- Excitable networks controlling cell migration during development and disease.Seminars in cell & developmental biology · 2020Review
- Article
- Modeling random crawling, membrane deformation and intracellular polarity of motile amoeboid cells.PloS one · 2018Article
- Modeling neutrophil migration in dynamic chemoattractant gradients: assessing the role of exosomes during signal relay.Molecular biology of the cell · 2017Article
- Rotational Diffusion of Soft Vesicles Filled by Chiral Active Particles.Scientific reports · 2017Article
- Discrete Modeling of Amoeboid Locomotion and Chemotaxis in Dictyostelium discoideum by Tracking Pseudopodium Growth Direction.Scientific reports · 2017Article
- Determining whether observed eukaryotic cell migration indicates chemotactic responsiveness or random chemokinetic motion.Journal of theoretical biology · 2017Article
- A critical-like collective state leads to long-range cell communication in Dictyostelium discoideum aggregation.PLoS biology · 2017Article
- Linking morphodynamics and directional persistence of T lymphocyte migration.Journal of the Royal Society, Interface · 2015Article
- The Berg-Purcell limit revisited.Biophysical journal · 2014Article
- Oscillatory behavior of neutrophils under opposing chemoattractant gradients supports a winner-take-all mechanism.PloS one · 2014Article
- Distinct cell shapes determine accurate chemotaxis.Scientific reports · 2013Article
- Migrating fibroblasts reorient directionality by a metastable, PI3K-dependent mechanism.The Journal of cell biology · 2012Article
- A stochastic description of Dictyostelium chemotaxis.PloS one · 2012Article
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1 author.
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Abstract
Many amoeboid cells move by extending pseudopods. Here I present a new stochastic model for chemotaxis that is based on pseudopod extensions by Dictyostelium cells. In the absence of external cues, pseudopod extension is highly ordered with two types of pseudopods: de novo formation of a pseudopod at the cell body in random directions, and alternating right/left splitting of an existing pseudopod that leads to a persistent zig-zag trajectory. We measured the directional probabilities of the extension of splitting and de novo pseudopods in chemoattractant gradients with different steepness. Very shallow cAMP gradients can bias the direction of splitting pseudopods, but the bias is not perfect. Orientation of de novo pseudopods require much steeper cAMP gradients and can be more precise. These measured probabilities of pseudopod directions were used to obtain an analytical model for chemotaxis of cell populations. Measured chemotaxis of wild-type cells and mutants with specific defects in these stochastic pseudopod properties are similar to predictions of the model. These results show that combining splitting and de novo pseudopods is a very effective way for cells to obtain very high sensitivity to stable gradient and still be responsive to changes in the direction of the gradient.
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