ArticleBiophysical journal2010
Tensile forces and shape entropy explain observed crista structure in mitochondria.
Article in Biophysical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Ablation of Sam50 is associated with fragmentation and alterations in metabolism in murine and human myotubes.Journal of cellular physiology · 2024Article
- Ablation ofbioRxiv : the preprint server for biology · 2023Article
- Mechanical instability generated by Myosin 19 contributes to mitochondria cristae architecture and OXPHOS.Nature communications · 2022Article
- Mitochondrial Cristae Architecture and Functions: Lessons from Minimal Model Systems.Membranes · 2021Review
- Mechanics of nuclear membranes.Journal of cell science · 2019Review
- Elastic membranes in confinement.Journal of the Royal Society, Interface · 2016Article
- Modeling of Mitochondrial Donut Formation.Biophysical journal · 2015Article
- Understanding shape entropy through local dense packing.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Biophysical significance of the inner mitochondrial membrane structure on the electrochemical potential of mitochondria.Physical review. E, Statistical, nonlinear, and soft matter physics · 2013Article
- Modeling and simulation of biological systems from image data.BioEssays : news and reviews in molecular, cellular and developmental biology · 2013Article
- Identification and analysis of putative homologues of mechanosensitive channels in pathogenic protozoa.PloS one · 2013Article
- Sam50 functions in mitochondrial intermembrane space bridging and biogenesis of respiratory complexes.Molecular and cellular biology · 2012Article
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Authors and funding
6 authors.
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Abstract
We present a model from which the observed morphology of the inner mitochondrial membrane can be inferred as minimizing the system's free energy. In addition to the usual energetic terms for bending, surface area, and pressure difference, our free energy includes terms for tension that we hypothesize to be exerted by proteins and for an entropic contribution due to many dimensions worth of shapes available at a given energy. We also present measurements of the structural features of mitochondria in HeLa cells and mouse embryonic fibroblasts using three-dimensional electron tomography. Such tomograms reveal that the inner membrane self-assembles into a complex structure that contains both tubular and flat lamellar crista components. This structure, which contains one matrix compartment, is believed to be essential to the proper functioning of mitochondria as the powerhouse of the cell. Interpreting the measurements in terms of the model, we find that tensile forces of ∼20 pN would stabilize a stress-induced coexistence of tubular and flat lamellar cristae phases. The model also predicts a pressure difference of -0.036 ± 0.004 atm (pressure higher in the matrix) and a surface tension equal to 0.09 ± 0.04 pN/nm.
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