ArticleBiophysical journal2010
Drosophila neurons actively regulate axonal tension in vivo.
Article in Biophysical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- Cellular mechanisms of traumatic brain injury.npj biological physics and mechanics · 2025Review
- Mechanical hierarchy in the formation and modulation of cortical folding patterns.Scientific reports · 2023Article
- Biomechanical models and mechanisms of cellular morphogenesis and cerebral cortical expansion and folding.Seminars in cell & developmental biology · 2023Review
- The role of mechanics in axonal stability and development.Seminars in cell & developmental biology · 2023Review
- Image-based axon model highlights heterogeneity in initiation of damage.Biophysical journal · 2023Article
- Mathematical models of neuronal growth.Biomechanics and modeling in mechanobiology · 2022Review
- Understanding, engineering, and modulating the growth of neural networks: An interdisciplinary approach.Biophysics reviews · 2021Review
- Manipulation of Axonal Outgrowth via Exogenous Low Forces.International journal of molecular sciences · 2020Review
- Axonal cytomechanics in neuronal development.Journal of biosciences · 2020Review
- Localized Axolemma Deformations Suggest Mechanoporation as Axonal Injury Trigger.Frontiers in neurology · 2020Article
- Mechanical characterization of squid giant axon membrane sheath and influence of the collagenous endoneurium on its properties.Scientific reports · 2019Article
- Preparation and Manipulation of Olfactory Epithelium Explant Cultures for Measurement of the Mechanical Tension of Individual Axons Using the Biomembrane Force Probe.Bio-protocol · 2019Article
- Microfluidics on the fly: Inexpensive rapid fabrication of thermally laminated microfluidic devices for live imaging and multimodal perturbations of multicellular systems.Biomicrofluidics · 2019Article
- Modeling the Axon as an Active Partner with the Growth Cone in Axonal Elongation.Biophysical journal · 2018Article
- Cytoskeletal Mechanisms of Axonal Contractility.Biophysical journal · 2018Article
- Physical Biology of Axonal Damage.Frontiers in cellular neuroscience · 2018Article
- The Regulation of Axon Diameter: From Axonal Circumferential Contractility to Activity-Dependent Axon Swelling.Frontiers in molecular neuroscience · 2018Review
- Utilizing a Structural Mechanics Approach to Assess the Primary Effects of Injury Loads Onto the Axon and Its Components.Frontiers in neurology · 2018Article
- Coupled circumferential and axial tension driven by actin and myosin influences in vivo axon diameter.Scientific reports · 2017Article
- Axon tension regulates fasciculation/defasciculation through the control of axon shaft zippering.eLife · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Several experiments have shown that mechanical forces significantly influence the initiation, growth, and retraction of neurites of cultured neurons. A similar role has long been suggested for mechanical forces in vivo, but this hypothesis has remained unverified due to the paucity of in vivo studies of neuronal mechanical behavior. In this study, we used high-resolution micromechanical force sensors to study the mechanical response of motor neurons in live Drosophila embryos. Our experiments showed that Drosophila neurons maintained a rest tension (1-13 nN) and behaved like viscoelastic solids (i.e., with a linear force-deformation response followed by force relaxation to steady state) in response to sustained stretching. More importantly, when the tension was suddenly diminished by a release of the externally applied force, the neurons contracted and actively generated force to restore tension, sometimes to a value close to their rest tension. In addition, axons that were slackened by displacing the neuromuscular junction contracted and became taut in 10-30 min. These observations are remarkably similar to results from in vitro studies and suggest that mechanical tension may also strongly influence neuronal behavior in vivo.
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