ArticleBiophysical journal2010
A continuous-binding cross-linker model for passive airway smooth muscle.
Article in Biophysical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Mitigation of airways responsiveness by deep inflation of the lung.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Airway Bistability Is Modulated by Smooth Muscle Dynamics and Length-Tension Characteristics.Biophysical journal · 2016Article
- Modeling the impairment of airway smooth muscle force by stretch.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Phenotype, endotype and patient-specific computational modelling for optimal treatment design in asthma.Drug discovery today. Disease models · 2015Article
- A computational model of the response of adherent cells to stretch and changes in substrate stiffness.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Modelling airway smooth muscle passive length adaptation via thick filament length distributions.Journal of theoretical biology · 2013Article
- An inverse power-law distribution of molecular bond lifetimes predicts fractional derivative viscoelasticity in biological tissue.Biophysical journal · 2013Article
- A progressive rupture model of soft tissue stress relaxation.Annals of biomedical engineering · 2013Article
- Fluidization, resolidification, and reorientation of the endothelial cell in response to slow tidal stretches.American journal of physiology. Cell physiology · 2012Article
- The importance of synergy between deep inspirations and fluidization in reversing airway closure.PloS one · 2012Article
- A multi-scale approach to airway hyperresponsiveness: from molecule to organ.Frontiers in physiology · 2012Article
- Multiscale mathematical models of airway constriction and disease.Pulmonary pharmacology & therapeutics · 2011Review
- Could an increase in airway smooth muscle shortening velocity cause airway hyperresponsiveness?American journal of physiology. Lung cellular and molecular physiology · 2011Article
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
Although the active properties of airway smooth muscle (ASM) have garnered much modeling attention, the passive mechanical properties are not as well studied. In particular, there are important dynamic effects observed in passive ASM, particularly strain-induced fluidization, which have been observed both experimentally and in models; however, to date these models have left an incomplete picture of the biophysical, mechanistic basis for these behaviors. The well-known Huxley cross-bridge model has for many years successfully described many of the active behaviors of smooth muscle using sliding filament theory; here, we propose to extend this theory to passive biological soft tissue, particularly ASM, using as a basis the attachment and detachment of cross-linker proteins at a continuum of cross-linker binding sites. The resulting mathematical model exhibits strain-induced fluidization, as well as several types of force recovery, at the same time suggesting a new mechanistic basis for the behavior. The model is validated by comparison to new data from experimental preparations of rat tracheal airway smooth muscle. Furthermore, experiments in noncontractile tissue show qualitatively similar behavior, suggesting support for the protein-filament theory as a biomechanical basis for the behavior.
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