ArticleBiophysical journal2010
Spatial dynamics of multistage cell lineages in tissue stratification.
Article in Biophysical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 55 citations in OpenAlex.
- A damage-structured PDE model of stem cell hierarchies: The dual role of dedifferentiation in tissue homeostasis and aging.PloS one · 2026Article
- Positional BMP signaling orchestrates villus length in the small intestine.Nature communications · 2025Article
- Migration and proliferation drive the emergence of patterns in co-cultures of differentiating vascular progenitor cells.Mathematical biosciences and engineering : MBE · 2024Article
- A multiscale chemical-mechanical model predicts impact of morphogen spreading on tissue growth.NPJ systems biology and applications · 2023Article
- Spatial dynamics of feedback and feedforward regulation in cell lineages.PLoS computational biology · 2022Article
- Regulatory feedback effects on tissue growth dynamics in a two-stage cell lineage model.Physical review. E · 2021Article
- Multiple morphogens and rapid elongation promote segmental patterning during development.PLoS computational biology · 2021Article
- Potential Osteoinductive Effects of Hydroxyapatite Nanoparticles on Mesenchymal Stem Cells by Endothelial Cell Interaction.Nanoscale research letters · 2021Article
- Modelling stem cell ageing: a multi-compartment continuum approach.Royal Society open science · 2020Article
- STOCHASTIC DYNAMICS OF CELL LINEAGE IN TISSUE HOMEOSTASIS.Discrete and continuous dynamical systems. Series B · 2019Article
- Multiscale modeling of layer formation in epidermis.PLoS computational biology · 2018Article
- Quantifying Lgr5-positive stem cell behaviour in the pyloric epithelium.Scientific reports · 2016Article
- Stochastic control of proliferation and differentiation in stem cell dynamics.Journal of mathematical biology · 2015Article
- Deciphering principles of morphogenesis from temporal and spatial patterns on the integument.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Article
- Interactions and tradeoffs between cell recruitment, proliferation, and differentiation affect CNS regeneration.Biophysical journal · 2014Article
- Mathematical model of adult stem cell regeneration with cross-talk between genetic and epigenetic regulation.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- A mathematical-biological joint effort to investigate the tumor-initiating ability of Cancer Stem Cells.PloS one · 2014Article
- Numerical Methods for Two-Dimensional Stem Cell Tissue Growth.Journal of scientific computing · 2014Article
- Temporal control of self-organized pattern formation without morphogen gradients in bacteria.Molecular systems biology · 2013Article
- Model on cell movement, growth, differentiation and de-differentiation: reaction-diffusion equation and wave propagation.The European physical journal. E, Soft matter · 2013Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
In developing and self-renewing tissues, terminally differentiated (TD) cell types are typically specified through the actions of multistage cell lineages. Such lineages commonly include a stem cell and multiple progenitor (transit-amplifying) cell stages, which ultimately give rise to TD cells. As the tissue reaches a tightly controlled steady-state size, cells at different lineage stages assume distinct spatial locations within the tissue. Although tissue stratification appears to be genetically specified, the underlying mechanisms that direct tissue lamination are not yet completely understood. Herein, we use modeling and simulations to explore several potential mechanisms that can be utilized to create stratification during developmental or regenerative growth in general systems and in the model system, the olfactory epithelium of mouse. Our results show that tissue stratification can be generated and maintained through controlling spatial distribution of diffusive signaling molecules that regulate the proliferation of each cell type within the lineage. The ability of feedback molecules to stratify a tissue is dependent on a low TD death rate: high death rates decrease tissue lamination. Regulation of the cell cycle lengths of stem cells by feedback signals can lead to transient accumulation of stem cells near the base and apex of tissue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.