ArticleZhongguo fei ai za zhi = Chinese journal of lung cancer2010
[Expression and significance of COX-2 and its transcription factors NFAT3 and c-Jun in non-small cell lung cancer].
Article in Zhongguo fei ai za zhi = Chinese journal of lung cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 3 citations in OpenAlex.
- COX-2 in lung cancer: Mechanisms, development, and targeted therapies.Chronic diseases and translational medicine · 2024Review
- NFATc4 Regulates Sox9 Gene Expression in Acinar Cell Plasticity and Pancreatic Cancer Initiation.Stem cells international · 2016Article
- The role of the NFAT signaling pathway in retinal neovascularization.Investigative ophthalmology & visual science · 2013Article
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4 authors at 1 institution in 1 country.
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Abstract
BACKGROUND AND
objectiveCyclooxygenases (COX), the key enzymes in the conversion of arachidonic acid (AA) to prostaglandins (PGs), are involved in initiation and progression of cancer. The aim of this study is to explore the relationship between the expressions of COX-2 and several transcription factors in non-small cell lung cancer.
methodsImmunohistochemistry was performed to assay the expression levels of COX-2, c-Fos, c-Jun and nuclear factor of activated T cells 3 (NFAT3) in tissue microarray containing 159 tumor tissues of non-small cell lung cancer.
resultsThe positive rate of COX-2 expression was 42.8%, and the expression of COX-2 was significantly higher in squamous cell carcinoma than that in adenocarcinoma (52.9% vs 31.3%, χ²=7.723, P=0.005). The expression of COX-2 was significantly associated with differentiation grade, with the lower level in the poorer differentiation grade group (χ²=7.600, P=0.022). In this panel of samples, the expression of COX-2 was significantly correlated with c-Fos expression (r=0.456, P<0.001) and NFAT3 level (r=0.294, P<0.001). The correlation between the expressions of NFAT3 and c-Fos were also observed (r=0.231, P=0.003).
conclusionThe expression of COX-2 was significantly associated with the expressions of transcription factors NFAT3 and c-Fos in nonsmall cell lung cancer.
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