ArticleBMC genomics2010
Analyses of genome architecture and gene expression reveal novel candidate virulence factors in the secretome of Phytophthora infestans.
Article in BMC genomics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers.
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102 citing papers in PubMed, 205 citations in OpenAlex.
- Isolation and proteomic analysis of intracellular vesicles from the potato late blight pathogen Phytophthora infestans.Scientific reports · 2026Article
- Comprehensive whole genome hybrid assembly unravels genes and secretome ofFrontiers in fungal biology · 2026Article
- Pathogenicity and virulence ofVirulence · 2025Review
- Enzymatic oxidation of galacturonides from pectin breakdown contributes to stealth infection by Oomycota phytopathogens.Nature communications · 2025Article
- Atypical RXLR effectors are involved inaBIOTECH · 2025Article
- Specific Transcriptional Regulation Controls Plant Organ-Specific Infection by the Oomycete Pathogen Phytophthora sojae.Molecular plant pathology · 2024Article
- Machine Learning-Based Identification of Mating Type and Metalaxyl Response inMicroorganisms · 2024Article
- Genomic and transcriptomic analyses ofFrontiers in microbiology · 2024Article
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- Deciphering the underlying immune network of the potato defense response inhibition byFrontiers in plant science · 2023Article
- Fungal Effectoromics: A World in Constant Evolution.International journal of molecular sciences · 2022Review
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- Unveiling the Secretome of the Fungal Plant PathogenJournal of fungi (Basel, Switzerland) · 2022Article
- A jacalin-like lectin domain-containing protein of Sclerospora graminicola acts as an apoplastic virulence effector in plant-oomycete interactions.Molecular plant pathology · 2022Article
- Short Linear Motifs (SLiMs) in "Core" RxLR Effectors ofMicrobiology spectrum · 2022Article
- Comparative Metabolomic Profiling of Compatible and Incompatible Interactions Between Potato andFrontiers in microbiology · 2022Article
- Dual RNA Sequencing Reveals the Genome-Wide Expression Profiles During the Compatible and Incompatible Interactions BetweenFrontiers in plant science · 2022Article
- "Core" RxLR effectors in phytopathogenic oomycetes: A promising way to breeding for durable resistance in plants?Virulence · 2021Article
- A whole genome duplication drives the genome evolution of Phytophthora betacei, a closely related species to Phytophthora infestans.BMC genomics · 2021Article
- A single amino acid polymorphism in a conserved effector of the multihost blast fungus pathogen expands host-target binding spectrum.PLoS pathogens · 2021Article
42 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPhytophthora infestans is the most devastating pathogen of potato and a model organism for the oomycetes. It exhibits high evolutionary potential and rapidly adapts to host plants. The P. infestans genome experienced a repeat-driven expansion relative to the genomes of Phytophthora sojae and Phytophthora ramorum and shows a discontinuous distribution of gene density. Effector genes, such as members of the RXLR and Crinkler (CRN) families, localize to expanded, repeat-rich and gene-sparse regions of the genome. This distinct genomic environment is thought to contribute to genome plasticity and host adaptation.
resultsWe used in silico approaches to predict and describe the repertoire of P. infestans secreted proteins (the secretome). We defined the "plastic secretome" as a subset of the genome that (i) encodes predicted secreted proteins, (ii) is excluded from genome segments orthologous to the P. sojae and P. ramorum genomes and (iii) is encoded by genes residing in gene sparse regions of P. infestans genome. Although including only ~3% of P. infestans genes, the plastic secretome contains ~62% of known effector genes and shows >2 fold enrichment in genes induced in planta. We highlight 19 plastic secretome genes induced in planta but distinct from previously described effectors. This list includes a trypsin-like serine protease, secreted oxidoreductases, small cysteine-rich proteins and repeat containing proteins that we propose to be novel candidate virulence factors.
conclusionsThis work revealed a remarkably diverse plastic secretome. It illustrates the value of combining genome architecture with comparative genomics to identify novel candidate virulence factors from pathogen genomes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.