ArticleParasites & vectors2010
Investigating the evolution of apoptosis in malaria parasites: the importance of ecology.
Article in Parasites & vectors, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Article
- Serratia marcescens and Enterobacter cloacae exhibit differential population dynamics in Anopheles gambiae s.l after sugar and blood feeding.Malaria journal · 2026Article
- Drug-induced ER stress leads to induction of programmed cell death pathways of the malaria parasite.Parasitology research · 2024Article
- Induction of apoptosis by double-stranded RNA was present in the last common ancestor of cnidarian and bilaterian animals.PLoS pathogens · 2024Article
- Extracellular vesicles carrying lactate dehydrogenase induce suicide in increased population density of Plasmodium falciparum in vitro.Scientific reports · 2019Article
- Discrimination Experiments in Entamoeba and Evidence from Other Protists Suggest Pathogenic Amebas Cooperate with Kin to Colonize Hosts and Deter Rivals.The Journal of eukaryotic microbiology · 2019Review
- Transmission traits of malaria parasites within the mosquito: Genetic variation, phenotypic plasticity, and consequences for control.Evolutionary applications · 2018Article
- Review
- WantedMicrobial cell (Graz, Austria) · 2015Review
- War and peace: social interactions in infections.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Injury and immune response: applying the danger theory to mosquitoes.Frontiers in plant science · 2014Article
- Costs of crowding for the transmission of malaria parasites.Evolutionary applications · 2013Article
- The first suicides: a legacy inherited by parasitic protozoans from prokaryote ancestors.Parasites & vectors · 2013Review
- Evolution of the animal apoptosis network.Cold Spring Harbor perspectives in biology · 2013Review
- Variation in apoptosis mechanisms employed by malaria parasites: the roles of inducers, dose dependence and parasite stages.Malaria journal · 2012Article
- Apoptosis and apoptotic mimicry in Leishmania: an evolutionary perspective.Frontiers in cellular and infection microbiology · 2012Review
- Enhanced transmission of drug-resistant parasites to mosquitoes following drug treatment in rodent malaria.PloS one · 2012Article
- On Programmed Cell Death in Plasmodium falciparum: Status Quo.Journal of tropical medicine · 2012Article
- The meaning of death: evolution and ecology of apoptosis in protozoan parasites.PLoS pathogens · 2011Review
- Evolution of apoptosis-like programmed cell death in unicellular protozoan parasites.Parasites & vectors · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Apoptosis is a precisely regulated process of cell death which occurs widely in multicellular organisms and is essential for normal development and immune defences. In recent years, interest has grown in the occurrence of apoptosis in unicellular organisms. In particular, as apoptosis has been reported in a wide range of species, including protozoan malaria parasites and trypanosomes, it may provide a novel target for intervention. However, it is important to understand when and why parasites employ an apoptosis strategy before the likely long- and short-term success of such an intervention can be evaluated. The occurrence of apoptosis in unicellular parasites provides a challenge for evolutionary theory to explain as organisms are expected to have evolved to maximise their own proliferation, not death. One possible explanation is that protozoan parasites undergo apoptosis in order to gain a group benefit from controlling their density as this prevents premature vector mortality. However, experimental manipulations to examine the ultimate causes behind apoptosis in parasites are lacking. In this review, we focus on malaria parasites to outline how an evolutionary framework can help make predictions about the ecological circumstances under which apoptosis could evolve. We then highlight the ecological considerations that should be taken into account when designing evolutionary experiments involving markers of cell death, and we call for collaboration between researchers in different fields to identify and develop appropriate markers in reference to parasite ecology and to resolve debates on terminology.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.