ArticleEuropean journal of clinical investigation1990
Tubular site of renal sodium retention in ascitic liver cirrhosis evaluated by lithium clearance.
Article in European journal of clinical investigation, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05999773 (Potential Role of Sodium Glucose Cotransporter 2 Inhibitors in the Treatment of Ascites in Cirrhotic Patients), which is not on this map. Cited by 28 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Potential Role of Sodium Glucose Cotransporter 2 Inhibitors in the Treatment of Ascites in Cirrhotic Patients
Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Guideline
- KASL clinical practice guidelines for liver cirrhosis: Ascites and related complications.Clinical and molecular hepatology · 2018Guideline
- Austrian consensus guidelines on the management and treatment of portal hypertension (Billroth III).Wiener klinische Wochenschrift · 2017Guideline
- The Value of T1 and T2 Mapping in Diagnosing Chronic Liver Disease-related Kidney Injury and Monitoring the Outcome of Stem Cell Therapy: An Animal Experimental Study.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2026Article
- Effect of empagliflozin on fractional excretion of sodium in patients with cirrhosis and refractory ascites.World journal of hepatology · 2025Article
- Seeing and Sensing the Hepatorenal Syndrome (HRS): The Growing Role of Ultrasound-Based Techniques as Non-Invasive Tools for the Diagnosis of HRS.Diagnostics (Basel, Switzerland) · 2024Review
- Serum lactate and mean arterial pressure thresholds in patients with cirrhosis and septic shock.Hepatology communications · 2024Observational
- Hepatorenal Syndrome-Novel Insights into Diagnostics and Treatment.International journal of molecular sciences · 2023Review
- Current knowledge about biomarkers of acute kidney injury in liver cirrhosis.Clinical and molecular hepatology · 2022Review
- Management of Ascites in Patients with Cirrhosis: An Update.Journal of clinical medicine · 2021Review
- Recent advances in the understanding and management of hepatorenal syndrome.Faculty reviews · 2021Review
- Short-term mortality in patients with cirrhosis of the liver and acute kidney injury: A prospective observational study.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2020Observational
- Acute kidney injury in critically ill cirrhotic patients with spontaneous bacterial peritonitis: a comparison of KDIGO and ICA criteria.Archives of medical science : AMS · 2020Article
- Acute kidney injury in children with chronic liver disease.Pediatric nephrology (Berlin, Germany) · 2019Review
- Acute kidney injury in patients with cirrhosis of liver: Clinical profile and predictors of outcome.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2018Observational
- Management of ascites and hepatorenal syndrome.Hepatology international · 2018Review
- Renal dysfunction in cirrhosis: acute kidney injury and the hepatorenal syndrome.Gastroenterology report · 2017Article
- Acute renal injury after partial hepatectomy.World journal of hepatology · 2016Review
- Incidence and risk factors for early renal dysfunction after liver transplantation.World journal of transplantation · 2016Article
- Drug therapies in liver disease.Clinical medicine (London, England) · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Renal tubular sodium handling was evaluated in 27 non-azotemic cirrhotic patients with ascites and positive sodium balance and in 17 controls after at least 5 days of a constant sodium intake using the lithium clearance as an index of fluid delivery to the distal tubule. Plasma renin activity and plasma aldosterone were also evaluated. Sodium fractional excretion, filtered sodium load, absolute sodium distal delivery, lithium fractional excretion and absolute distal sodium reabsorption were significantly lower in cirrhotics than in controls (0.58 +/- 0.11 vs. 1.29 +/- 0.12%, P less than 0.001; 12529 +/- 677 vs. 15707 +/- 796 microEq min-1 1.73 m-2 BSA, P less than 0.005; 2384 +/- 135.2 vs. 3685 +/- 219.3 microEq min-1 1.73 m-2 BSA, P less than 0.001; 19.5 +/- 1.0 vs. 24.2 +/- 1.3%, P less than 0.01; 2299 +/- 127 vs. 3485 +/- 214 microEq min-1 1.73 m-2 BSA, P less than 0.001, respectively). A correlation was found between lithium clearance and sodium clearance only in cirrhotic patients (r = 0.62; P less than 0.01). Distal sodium reabsorption evaluated as a per cent of filtered sodium load was lower in cirrhotics than in controls (19.1 +/- 1.0 vs. 22.4 +/- 1.2%, P less than 0.05) while distal sodium reabsorption evaluated as a per cent of sodium distal delivery was higher in cirrhotics than in controls (96.7 +/- 0.4 vs. 94.4 +/- 0.5%, P less than 0.005).(ABSTRACT TRUNCATED AT 250 WORDS)
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.