Evidence map›Paper›PMID 21080245›Full record

ArticleCurrent gastroenterology reports2011

A clinical perspective on gastric neuroendocrine neoplasia.

Ben Lawrence, Mark Kidd, Bernhard Svejda, Irvin Modlin

Abstract read
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In one paragraph

Article in Current gastroenterology reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. [Endoscopic therapy for gastroduodenal neuroendocrine neoplasms].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2016
    Review
  11. Review
  12. Review
  13. Ki-67 is a reliable pathological grading marker for neuroendocrine tumors.Virchows Archiv : an international journal of pathology · 2013
    Article
  14. Article
  15. Article
  16. Current concepts on gastric carcinoid tumors.Gastroenterology research and practice · 2012
    Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ben LawrenceYale University School of Medicine, New Haven, CT 06520, USA. benjamin.lawrence@yale.edu
Mark Kidd
Bernhard Svejda
Irvin Modlin
Yale University · US

Funding

Mechanisms of abnormal enterochromaffin cell secretion in Crohn's diseaseR01DK080871 · NIDDK · YALE UNIVERSITY · PI KIDD, MARK S · 2009 to 2012
$1.4M
NIDDK NIH HHS DK080871
6 · The paper itself

Abstract

The incidence of gastric neuroendocrine tumors (NETs) has increased exponentially based on widespread use of endoscopy and a greater pathological awareness of the condition. A key concern is the potential association with hypergastrinemia induced by proton pump inhibitor administration. Previous confusion regarding diagnosis and therapy has been diminished by a series of international consensus statements defining the biology and management strategies for the disease. Overall, gastric NETs are categorized as well-differentiated or poorly differentiated neoplasms. Well-differentiated gastric NETs are enterochromaffin-like (ECL) cell tumors subclassified into three types based on their relationship to gastrin, a key regulator of ECL cell neoplastic transformation. The treatment of type 1 and type 2 tumors depends on the size and invasiveness of the tumor, whereas type 3 tumors and poorly differentiated neuroendocrine carcinomas warrant aggressive surgical resection. The disease-specific 5-year survival ranges from about 95% in type 1 gastric carcinoids to about 25% in poorly differentiated gastric NECs. Elucidation of the precise biology of a gastric NET is critical to diagnosis and delineation of a type-specific management strategy.

Indexed as

Carcinoid TumorCarcinoma, NeuroendocrineCell Transformation, NeoplasticEnterochromaffin-like CellsGastroscopyHumansIncidenceNeoplasm InvasivenessNeoplasm StagingNeuroendocrine TumorsPrognosisStomach Neoplasms

Identifiers

PMID21080245
OpenAlexW2022085249

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.