ArticleMolecular imaging and biology2011
Impact of indium-111 oxine labelling on viability of human mesenchymal stem cells in vitro, and 3D cell-tracking using SPECT/CT in vivo.
Article in Molecular imaging and biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it.
- MRI Guided Focused Ultrasound-Mediated Delivery of Therapeutic Cells to the Brain: A Review of the State-of-the-Art Methodology and Future Applications.Frontiers in neurology · 2021Pooled it
- Stem cells therapy molecular tracking - the special focus on nuclear medicine.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2026Review
- Advances in Tracing Techniques: Mapping the Trajectory of Mesenchymal Stem-Cell-Derived Extracellular Vesicles.Chemical & biomedical imaging · 2025Review
- An indium-111-labelled membrane-targeted peptide for cell tracking with radionuclide imaging.RSC chemical biology · 2023Article
- Single-photon emission computed tomography as a fundamental tool in evaluation of myocardial reparation and regeneration therapies.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2022Review
- Iron Oxide Nanoparticles in Mesenchymal Stem Cell Detection and Therapy.Stem cell reviews and reports · 2022Review
- In vivo observation of multi-phase spatiotemporal cellular dynamics of transplanted HSPCs during early engraftment.FASEB bioAdvances · 2022Article
- Direct Cell Radiolabeling forChemical reviews · 2022Review
- In vivo tracking of unlabelled mesenchymal stromal cells by mannose-weighted chemical exchange saturation transfer MRI.Nature biomedical engineering · 2022Article
- Options for imaging cellular therapeutics in vivo: a multi-stakeholder perspective.Cytotherapy · 2021Review
- Characterization of Intrinsically Radiolabeled Poly(lactic-Bioconjugate chemistry · 2021Article
- NoninvasiveWorld journal of stem cells · 2020Review
- Radical Dendrimers Based on Biocompatible Oligoethylene Glycol Dendrimers as Contrast Agents for MRI.Pharmaceutics · 2020Article
- Multi-modal imaging probe for assessing the efficiency of stem cell delivery to orthotopic breast tumours.Nanoscale · 2020Article
- Increased Myocardial Retention of Mesenchymal Stem Cells Post-MI by Pre-Conditioning Exercise Training.Stem cell reviews and reports · 2020Article
- Clinical cancer research : an official journal of the American Association for Cancer Research · 2020Article
- Relevance of immune cell and tumor microenvironment imaging in the new era of immunotherapy.Journal of experimental & clinical cancer research : CR · 2020Review
- Radiolabeling and Imaging of Adoptively Transferred Immune Cells by Positron Emission Tomography.Methods in molecular biology (Clifton, N.J.) · 2020Article
- Imaging Gliomas with Nanoparticle-Labeled Stem Cells.Chinese medical journal · 2018Review
- Genetic engineered molecular imaging probes for applications in cell therapy: emphasis on MRI approach.American journal of nuclear medicine and molecular imaging · 2016Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study investigates the effects of (111)In-oxine incorporation on human mesenchymal stem cells' (hMSC) biology and viability, and the applicability of (111)In-oxine for single-photon emission computed tomography/X-ray computed tomography (SPECT/CT) monitoring of hMSC in vivo. PROCEDURES: HMSC were labelled with 10 Bq/cell. Cellular retention of radioactivity, cell survival, and migration were evaluated over 48 h. Metabolic activity was assessed over 14 days and the hMSC's stem cell character was evaluated. Serial SPECT/CT was performed after intra-osseous injection to athymic rats over 48 h.
resultsLabelling efficiency was 25%, with 61% of incorporated (111)In remaining in the hMSC at 48 h. The radiolabelling was without effect on cell viability, stem cell character, and plasticity, whereas metabolic activity and migration were significantly reduced. Grafted cells could be imaged in situ with SPECT/CT.
conclusions(111)In-oxine labelling moderately impaired hMSC's functional integrity while preserving their stem cell character. Combined SPECT/CT imaging of (111)In-oxine-labelled hMSC opens the possibility for non-invasive sequential monitoring of therapeutic stem cells.
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Registered trials
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