Trial reportLung2011
Oxygen uptake, ventilation, and symptoms during low-frequency versus high-frequency NMES in COPD: a pilot study.
Trial report in Lung, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 4 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- 20 years of neuromuscular electrical stimulation in COPD.European respiratory review : an official journal of the European Respiratory Society · 2024Pooled it
- Neuromuscular electrostimulation for adults with chronic obstructive pulmonary disease.The Cochrane database of systematic reviews · 2018Pooled it
- Neuromuscular electrical stimulation for muscle weakness in adults with advanced disease.The Cochrane database of systematic reviews · 2016Pooled it
- Effectiveness of neuromuscular electrical stimulation for the rehabilitation of moderate-to-severe COPD: a meta-analysis.International journal of chronic obstructive pulmonary disease · 2016Pooled it
- Metabolic load during strength training or NMES in individuals with COPD: results from the DICES trial.BMC pulmonary medicine · 2014Trial
- Feasibility and acceptability of whole-body electromyostimulation in pulmonary rehabilitation for patients with chronic respiratory disease: a pilot study protocol.Pilot and feasibility studies · 2026Review
- Effects of pelvic floor electrical stimulation with an implantable device at different frequencies on stress urinary incontinence in rats.European journal of medical research · 2025Article
- The feasibility of conducting successful pulmonary rehabilitation in India.Journal of Yeungnam medical science · 2025Article
- Exercise assessments and trainings of pulmonary rehabilitation in COPD: a literature review.International journal of chronic obstructive pulmonary disease · 2018Review
- Article
- Effects of Neuromuscular Electrical Stimulation Training on Endurance Performance.Frontiers in physiology · 2016Article
- Pulmonary rehabilitation.European respiratory review : an official journal of the European Respiratory Society · 2014Review
- Musculoskeletal disorders in chronic obstructive pulmonary disease.BioMed research international · 2014Review
- Acute microcirculatory effects of medium frequency versus high frequency neuromuscular electrical stimulation in critically ill patients - a pilot study.Annals of intensive care · 2013Article
- Validation of the oxycon mobile metabolic system in healthy subjects.Journal of sports science & medicine · 2012Article
- Task-related oxygen uptake and symptoms during activities of daily life in CHF patients and healthy subjects.European journal of applied physiology · 2011Article
- Neuromuscular Electrical Stimulation for Treatment of Muscle Impairment: Critical Review and Recommendations for Clinical Practice.Physiotherapy Canada. Physiotherapie CanadaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcutaneous neuromuscular electrical stimulation (NMES) involves the application of an electrical current through electrodes placed on the skin over the targeted muscles. During high-frequency NMES (HF-NMES), oxygen uptake, minute ventilation, and the degree of symptom perception (dyspnea and fatigue) have been shown to be acceptable in chronic obstructive pulmonary disease (COPD). Currently, oxygen uptake and ventilation load have never been assessed during low-frequency NMES (LF-NMES) of the lower-limb muscles. The purpose of this study was to compare prospectively oxygen uptake, ventilation, and symptom perception during a single session of LF-NMES versus a single session of HF-NMES of quadriceps muscles in patients with COPD. In 17 COPD patients (mean FEV(1) = 45% predicted, mean body mass index = 26.2 kg/m(2)), peak exercise capacity, functional exercise capacity, and the Medical Research Council dyspnea grade were evaluated. In addition, oxygen uptake, minute ventilation, heart rate, and Borg symptom scores were assessed during one session of LF-NMES (15 Hz) and one session of HF-NMES (75 Hz) and compared with peak values. Mean oxygen uptake (LF-NMES: 327 ml/min vs. HF-NMES: 315 ml/min), minute ventilation (LF-NMES: 14 L vs. HF-NMES: 15 L), and heart rate (LF-NMES: 86 BPM vs. HF-NMES: 83 BPM) were similar during both NMES frequencies. Patients used a relatively low proportion of their peak aerobic capacity during both NMES sessions (LF-NMES: 34% vs. HF-NMES: 33%; P = 0.397). In addition, symptom Borg scores for dyspnea and leg fatigue were also comparable. Oxygen uptake, ventilation, and symptoms of dyspnea and fatigue were comparable and tolerable during LF-NMES and HF-NMES in patients with COPD. Therefore, LF-NMES and HF-NMES may both be suitable rehabilitative modalities to be used in severely dyspneic patients with lower-limb muscle dysfunction.
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