ArticleNeuroradiology2011
Pineal parenchymal tumor of intermediate differentiation: imaging spectrum of an unusual tumor in 11 cases.
Article in Neuroradiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Pineal parenchymal tumor of intermediate differentiation: a systematic review and contemporary management of 389 cases reported during the last two decades.Neurosurgical review · 2022Pooled it
- Pineal Gland Parenchyma Tumors.Advances and technical standards in neurosurgery · 2026Review
- Imaging of Pineal Region Masses.Advances and technical standards in neurosurgery · 2026Review
- Pineal parenchymal tumor of intermediate differentiation: Case series and literature review: Is it time for a consensus?Surgical neurology international · 2025Article
- Pineal Parenchymal Tumors of Intermediate Differentiation: A Case Report and Literature Review.Cureus · 2023Article
- Pineal parenchymal tumor of intermediate differentiation with late spinal dissemination 13 years after initial surgery: illustrative case.Journal of neurosurgery. Case lessons · 2023Article
- Radiation therapy for pineal parenchymal tumor of intermediate differentiation: A case series and literature review.Journal of central nervous system disease · 2023Article
- Neuroimaging of paediatric pineal, sellar and suprasellar tumours: a guide to differential diagnosis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022Review
- Pineal parenchymal tumor of intermediate differentiation: a single-institution experience.Neuro-oncology practice · 2020Article
- Magnetic resonance imaging of pineal tumors and drop metastases: a review approach.Rare tumors · 2017Article
- Histopathologic review of pineal parenchymal tumors identifies novel morphologic subtypes and prognostic factors for outcome.Neuro-oncology · 2017Article
- Pineal parenchymal tumour of intermediate differentiation: a rare differential diagnosis of pineal region tumours.BJR case reports · 2016Article
- Upfront Stereotactic Radiosurgery for Pineal Parenchymal Tumors in Adults.Journal of Korean Neurosurgical Society · 2015Article
- Diffusion characteristics of pediatric pineal tumors.The neuroradiology journal · 2015Article
- Neuroimaging diagnosis of pineal region tumors-quest for pathognomonic finding of germinoma.Neuroradiology · 2014Article
- The new World Health Organization Classification of Central Nervous System Tumors: what can the neuroradiologist really say?AJNR. American journal of neuroradiology · 2012Review
- Distinguishing between germinomas and pineal cell tumors on MR imaging.AJNR. American journal of neuroradiology · 2012Article
- Survival and associated predictors for patients with pineoblastoma or pineal parenchymal tumors of intermediate differentiation older than 3 years: Insights from the National Cancer Database.Neuro-oncology advancesArticle
- Genetic landscape and molecular targets in pediatric pineal tumors.Neuro-oncology advancesReview
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPineal parenchymal tumor of intermediate differentiation (PPTID) was recognized in the 2007 World Health Organization (WHO) classification as a new pineal parenchymal neoplasm, intermediate in malignancy (WHO grade II or III) between pineocytoma (grade I) and pineoblastoma (grade IV). The imaging spectrum of this new tumor has not been previously delineated. We describe the imaging spectrum in 11 pathologically proven PPTIDs and identify findings that may suggest the preoperative diagnosis of this newly recognized entity.
methodsElectronic medical records over the last 9 years and teaching files between the years 1985 and 1995 were searched for atypical pineal lesions. Additional cases were added from the teaching files of contributing authors.
resultsImaging studies in nine patients (9/11) showed bulky, aggressive pineal region masses with local brain invasion; two patients (2/11) demonstrated circumscribed pineal masses. Two patients had spinal metastases at presentation. On computed tomography (CT), five patients had classic "exploded" calcifications characteristic of pineal parenchymal tumors. All tumors were heterogeneously hypointense on T1WIs and heterogeneously hyperintense on T2WIs. Post-contrast scans showed marked heterogeneous (10/11) or uniform (1/11) enhancement. Cystic foci were identified in eight cases. Intratumoral hemorrhage was present in one case.
conclusionWhile no singular neuroimaging feature is pathognomonic of PPTID, these tumors are usually larger, demonstrate local invasion, and appear much more heterogeneous than pineocytoma. Because PPTIDs have a higher grade and increased potential for recurrence as compared to pineocytomas, it is important to consider this diagnosis as shorter follow-up, and adjuvant therapy may be indicated in selected cases.
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