Trial reportWorld journal of pediatrics : WJP2010
A randomized, triple masked, placebo-controlled clinical trial for controlling childhood obesity.
Trial report in World journal of pediatrics : WJP, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 7 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Interventions for Childhood Central Obesity: A Systematic Review and Meta-Analysis.JAMA network open · 2025Pooled it
- Pharmacological interventions for addressing pediatric and adolescent obesity: A systematic review and network meta-analysis.PloS one · 2025Pooled it
- Role of metformin in overweight and obese people without diabetes: a systematic review and network meta-analysis.European journal of clinical pharmacology · 2019Pooled it
- The effects of metformin on simple obesity: a meta-analysis.Endocrine · 2018Pooled it
- Pediatric Obesity-Assessment, Treatment, and Prevention: An Endocrine Society Clinical Practice Guideline.The Journal of clinical endocrinology and metabolism · 2017 · on this mapGuideline
- Drug interventions for the treatment of obesity in children and adolescents.The Cochrane database of systematic reviews · 2016Pooled it
- School-based physical activity programs for promoting physical activity and fitness in children and adolescents aged 6 to 18.The Cochrane database of systematic reviews · 2013Pooled it
- Trial
- Vicious cycle between severity of childhood obesity and pandemic: Potential impact of metformin.Obesity medicine · 2022Article
- Maternal Gestational Weight Gain in Relation to Antidepressant Continuation in Pregnancy.American journal of perinatology · 2021Article
- Regulation of emotional response in juvenile monkeys treated with fluoxetine: MAOA interactions.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2016Article
- Pediatric obesity pharmacotherapy: current state of the field, review of the literature and clinical trial considerations.International journal of obesity (2005) · 2016Review
- Controlling childhood obesity: A systematic review on strategies and challenges.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2014Review
- An evolving scientific basis for the prevention and treatment of pediatric obesity.International journal of obesity (2005) · 2014Review
- The therapy of insulin resistance in other diseases besides type 2 diabetes.Eating and weight disorders : EWD · 2014Review
- Pharmacotherapy for childhood obesity: present and future prospects.International journal of obesity (2005) · 2013Review
- Rational use of medicine in the pediatric age group: A summary on the role of clinical pharmacists.Journal of research in pharmacy practice · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe efficacy of pharmacological treatment in controlling childhood obesity is controversial. We aimed to compare the effects of three types of drug regimens and placebo on generalized and abdominal obesity among obese children and adolescents who did not succeed to lose weight 3 months after lifestyle modification (diet and exercise).
methodsThis triple-masked randomized clinical trial was conducted among 180 participants aged 10-16 years. They were assigned randomly to 4 groups of equal number to receive metformin, fluoxetine, a combination of the two drugs, or placebo. The trial lasted for 12 weeks and participants were followed up for an additional 12-week period.
resultsOverall, 91.1% (n=164) of the enrolled participants completed the trial. After the 12-week trial, the body mass index decreased significantly in all groups receiving medications [approximately -1.2 (0.2) kg/m², P<0.05]. This decrease was not significant in the placebo group. Waist circumference decreased significantly in the groups receiving metformin [-2.1 (0.4) cm, P=0.03)] as well as in the group receiving a combination therapy of metformin and fluoxetine [-2.5 (0.4) cm, P=0.01)]. In the 24-week follow-up study, these anthropometric indexes were lower than the baseline in the group that had received a combination therapy of metformin and fluoxetine. No serious drug side-effects were reported.
conclusionsA limited period of such treatment may help weight control, and might be used to encourage those children who have been refractory to weight loss for continuing the non-pharmacological programs. Our findings should be confirmed in future studies with a longer follow-up period.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.