Evidence map›Paper›PMID 21080058›Full record

ArticleCellular and molecular neurobiology2010

Down-modulation of Ca2+ channels by endogenously released ATP and opioids: from the isolated chromaffin cell to the slice of adrenal medullae.

A Hernández, P Segura-Chama, E Albiñana, A Hernández-Cruz, J M Hernández-Guijo

Open access · greenAbstract read
In one paragraph

Article in Cellular and molecular neurobiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Roles of NaPflugers Archiv : European journal of physiology · 2018
    Review
  4. GABAPflugers Archiv : European journal of physiology · 2018
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

A HernándezDepartamento de Neurociencia Cognitiva, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad Universitaria, México, DF 04510, México.
P Segura-Chama
E Albiñana
A Hernández-Cruz
J M Hernández-Guijo
Universidad Nacional Autónoma de México · MXUniversidad Autónoma de Madrid · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Modifications in Ca(2+) influx may lead to profound changes in the cell activity associated with Ca(2+)-dependent processes, from muscle contraction and neurotransmitter release to calcium-mediated cell death. Therefore, calcium entry into the cell requires fine regulation. In this context, understanding of the modulation of voltage-dependent Ca(2+) channels seems to be critical. The modulatory process results in the enhancement or decrement of calcium influx that may regulate the local and global cytosolic Ca(2+) concentrations. Here, we summarize the well-established data on this matter described in isolated chromaffin cells by our laboratory and others, and the new results we have obtained in a more physiological preparation: freshly isolated slices of mouse adrenal medullae.

Indexed as

Down-RegulationMembrane PotentialsAdenosine TriphosphateAdrenal MedullaAnalgesics, OpioidAnimalsAutocrine CommunicationCalcium ChannelsCalcium Channels, L-TypeCell SeparationChromaffin CellsGTP-Binding ProteinsIn Vitro TechniquesIon Channel GatingMiceNeurotransmitter AgentsAdenosine TriphosphateAnalgesics, OpioidCalcium ChannelsCalcium Channels, L-TypeGTP-Binding ProteinsNeurotransmitter Agents

Identifiers

PMID21080058
PMCPMC11498769
OpenAlexW2170560455

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.