ReviewPediatric nephrology (Berlin, Germany)2011
Uraemic vasculopathy in children with chronic kidney disease: prevention or damage limitation?
Review in Pediatric nephrology (Berlin, Germany), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Malnutrition and its association with inflammation and vascular disease in children on maintenance dialysis.Pediatric nephrology (Berlin, Germany) · 2013Trial
- The Source Matters-Effects of High Phosphate Intake from Eight Different Sources in Dogs.Animals : an open access journal from MDPI · 2021Article
- Interdialytic weight gain and vasculopathy in children on hemodialysis: a single center study.Pediatric nephrology (Berlin, Germany) · 2018Article
- Why are kids with lupus at an increased risk of cardiovascular disease?Pediatric nephrology (Berlin, Germany) · 2016Review
- Nocturnal intermittent hemodialysis.Pediatric nephrology (Berlin, Germany) · 2015Review
- Cardiovascular changes during chronic hypertensive states.Pediatric nephrology (Berlin, Germany) · 2014Review
- Hemodiafiltration in a pediatric nocturnal dialysis program.Pediatric nephrology (Berlin, Germany) · 2014Article
- Intensified hemodialysis in adults, and in children and adolescents.Deutsches Arzteblatt international · 2014Review
- Cardiovascular risk assessment in children with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2013Review
- Phosphate is a vascular toxin.Pediatric nephrology (Berlin, Germany) · 2013Review
- Intima media thickness in children undergoing dialysis.Pediatric nephrology (Berlin, Germany) · 2012Article
- Glucose intolerance: is it a risk factor for cardiovascular disease in children with chronic kidney disease?Pediatric nephrology (Berlin, Germany) · 2012Article
- Cardiovascular complications in children with chronic kidney disease.Nature reviews. Nephrology · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since the inception of pediatric dialysis programmes nearly 50 years ago, there have been vast improvements in both the technology and expertise in the care of children with chronic kidney disease (CKD). Nevertheless, children on dialysis continue to have a significantly higher mortality than their healthy peers and cardiovascular disease (CVD) is the most common cause of death in this group. Chronic kidney disease is described as the "perfect storm" of risk factors for CVD development, and vascular calcification is a highly regulated cell-mediated process with several promoters and inhibitors of calcification. CVD begins early in the course of CKD and there is an independent and graded association between cardiovascular morbidity and renal decline. Also, it is shown that once vascular damage and calcification begin, they progress inexorably in the uraemic milieu and may only be partially reversed after successful transplantation. Thus, preventing the development of CVD is key, and early identification and management of specific CVD-related risk factors should begin from the early stages of CKD. While the vasculopathy of childhood CKD is clearly multifactorial, clinical, epidemiological and cell biology studies provide converging evidence pointing to the role of dysregulated mineral metabolism as an important modifiable risk factor in the development of vascular calcification. In this review we focus on the role of calcium, phosphate, parathyroid hormone and vitamin D in ectopic vascular calcification, and discuss the role of screening, early intervention and management of established vascular calcification.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.