ArticleClinical & experimental metastasis
Enhancement of experimental metastatic ability by tumor necrosis factor-alpha alone or in combination with interferon-gamma.
Article in Clinical & experimental metastasis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 40 citations in OpenAlex.
- Inhibition of interferon-gamma-stimulated melanoma progression by targeting neuronal nitric oxide synthase (nNOS).Scientific reports · 2022Article
- In situ vaccination with defined factors overcomes T cell exhaustion in distant tumors.The Journal of clinical investigation · 2019Article
- Encapsulation in liposomal nanoparticles enhances the immunostimulatory, adjuvant and anti-tumor activity of subcutaneously administered CpG ODN.Cancer immunology, immunotherapy : CII · 2007Article
- CpG-Oligodeoxynucleotides activate tyrosinase-related protein 2-specific T lymphocytes but do not lead to a protective tumor-specific memory response.Cancer immunology, immunotherapy : CII · 2004Article
- Alpha-galactosylceramide (KRN7000) suppression of chemical- and oncogene-dependent carcinogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Biological properties associated with the enhanced lung-colonizing potential in a B16 murine melanoma line grown in a medium conditioned by syngeneic Corynebacterium parvum-elicited macrophages.Clinical & experimental metastasis · 1999Article
- Enhancement of lung-colonizing potential of murine tumor cell lines co-cultivated with activated macrophages.Clinical & experimental metastasis · 1997Article
- In vivo priming of two distinct antitumor effector populations: the role of MHC class I expression.The Journal of experimental medicine · 1994Article
- A novel Mutein of TNFalpha Containing the Arg-Gly-Asp Sequence Shows Reduced Toxicity in Intestine.Mediators of inflammation · 1994Article
- Expression of matrix metalloproteinase 9 (92-kDa gelatinase/type IV collagenase) induced by tumour necrosis factor alpha correlates with metastatic ability in a human osteosarcoma cell line.Virchows Archiv : an international journal of pathology · 1994Article
- Enhancement of experimental metastasis by tumor necrosis factor.The Journal of experimental medicine · 1993Article
- A YIGSR-containing novel mutein without the detrimental effect of human TNF-alpha of enhancing experimental pulmonary metastasis.Clinical & experimental metastasis · 1992Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effects of recombinant tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) on B16 mouse melanoma experimental metastatic ability and major histocompatibility complex (H-2b) antigens expression were studied. B16 cells exposed in vitro to TNF-alpha had an increased H-2 expression and were more metastatic than untreated cells. The simultaneous treatment with TNF-alpha and IFN-gamma amplified the enhancement of experimental metastasis and all other effects obtained with TNF-alpha alone. The B16 clone B78H1, selectively resistant to H-2 induction and to enhancement of metastatic ability by IFN-gamma, was not affected by treatment with TNF-alpha and with TNF-alpha + IFN-gamma. These findings contribute to a better understanding of the pleiotropic effects of TNF, some of which can have opposing actions in the complex tumor-host relationships.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.