ArticlePloS one2010
Differential volatile signatures from skin, naevi and melanoma: a novel approach to detect a pathological process.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Volatile organic compounds analysis as a potential novel screening tool for colorectal cancer: A systematic review and meta-analysis.Medicine · 2020Pooled it
- Reflectance confocal microscopy for diagnosing cutaneous melanoma in adults.The Cochrane database of systematic reviews · 2018Pooled it
- Optical coherence tomography for diagnosing skin cancer in adults.The Cochrane database of systematic reviews · 2018Pooled it
- Exhaled breath analysis with the use of an electronic nose to predict response to immune checkpoint inhibitors in patients with metastatic melanoma: melaNose trial.Frontiers in immunology · 2025Trial
- Exploratory Volatilome Profiling of Inflammation in Skin Fibroblasts: A Proof-of-Concept Study.International journal of molecular sciences · 2026Article
- Colorectal Cancer Diagnosis through Breath Test Using a Portable Breath Analyzer-Preliminary Data.Sensors (Basel, Switzerland) · 2024Article
- Skin Cancer Metabolic Profile Assessed by Different Analytical Platforms.International journal of molecular sciences · 2023Review
- The Human Skin Volatolome: A Systematic Review of Untargeted Mass Spectrometry Analysis.Metabolites · 2022Review
- Current Knowledge in Skin Metabolomics: Updates from Literature Review.International journal of molecular sciences · 2022Review
- Volatolomics in healthcare and its advanced detection technology.Nano research · 2022Review
- New Advances in Tissue Metabolomics: A Review.Metabolites · 2021Review
- Profiles of Volatile Biomarkers Detect Tuberculosis from Skin.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Needle Trap Device-GC-MS for Characterization of Lung Diseases Based on Breath VOC Profiles.Molecules (Basel, Switzerland) · 2021Article
- Volatile compounds emission from teratogenic human pluripotent stem cells observed during their differentiation in vivo.Scientific reports · 2018Article
- Volatile metabolomic signature of bladder cancer cell lines based on gas chromatography-mass spectrometry.Metabolomics : Official journal of the Metabolomic Society · 2018Article
- Detection of gas components as a novel diagnostic method for colorectal cancer.Annals of gastroenterological surgery · 2018Article
- Solid-phase microextraction technology forTrends in analytical chemistry : TRAC · 2016Article
- Blood volatile compounds as biomarkers for colorectal cancer.Cancer biology & therapy · 2014Article
- Review of mass spectrometry-based metabolomics in cancer research.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2013Review
- Direct Analysis in Real Time Mass Spectrometry (DART-MS) Analysis of Skin Metabolome Changes in the Ultraviolet B-Induced Mice.Biomolecules & therapeutics · 2013Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundEarly detection of melanoma is of great importance to reduce mortality. Discovering new melanoma biomarkers would improve early detection and diagnosis. Here, we present a novel approach to detect volatile compounds from skin. METHODS AND
findingsWe used Head Space Solid Phase Micro-Extraction (HS-SPME) and gas chromatography/mass spectrometry (GC/MS) to identify volatile signatures from melanoma, naevi and skin samples. We hypothesized that the metabolic state of tissue alters the profile of volatile compounds. Volatiles released from fresh biopsy tissue of melanoma and benign naevus were compared based on their difference in frequency distribution and their expression level. We also analyzed volatile profiles from frozen tissue, including skin and melanoma.
conclusionsThree volatiles, 4-methyl decane, dodecane and undecane were preferentially expressed in both fresh and frozen melanoma, indicating that they are candidate biomarkers. Twelve candidate biomarkers evaluated by fuzzy logic analysis of frozen samples distinguished melanoma from skin with 89% sensitivity and 90% specificity. Our results demonstrate proof-of-principle that there is differential expression of volatiles in melanoma. Our volatile metabolomic approach will lead to a better understanding of melanoma and can enable development of new diagnostic and treatment strategies based on altered metabolism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.