Evidence map›Paper›PMID 21079721›Full record

ReviewDeutsches Arzteblatt international2010

Nausea and vomiting after surgery under general anesthesia: an evidence-based review concerning risk assessment, prevention, and treatment.

Dirk Rüsch, Leopold H J Eberhart, Jan Wallenborn, Peter Kranke

3 registry-linked trialsOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Deutsches Arzteblatt international, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 65 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 5 pooled it
6.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02541019 phase4completednot on this mapstarted 2015, after this paper: background citation

Prophylactic Antiemetic Efficacy of Palonosetron Versus Ondansetron for the Prophylaxis of Postoperative Nausea and Vomiting (PONV) in Women Over 60 Years Undergoing Laparoscopic Cholecystectomy

TypeinterventionalSponsorHospital Federal de BonsucessoRan2015 to 2017Enrolled80ConditionsPostoperative Nausea and VomitingArmsOndansetron, Palonosetron
NCT05560542 nacompletednot on this mapstarted 2022, after this paper: background citation

Prophylactic Efficacy and Safety of Intrathecal Dexamethasone, Atropine or Their Combination on Morphine Induced Post-operative Nausea and Vomiting on Patients Undergoing Caesarean Section With Spinal Anaesthesia

TypeinterventionalSponsorAssiut UniversityRan2022 to 2025Enrolled150ConditionsMorphine Adverse ReactionArmsAtropine and Dexamethasone
NCT06632184 phase4active not recruitingnot on this mapstarted 2025, after this paper: background citation

Pilot Comparative Study on the Efficacy of Multimodal Management With Peritoneal Lavage Using Saline Solution Versus Saline Solution With Ondansetron in Laparoscopic Cholecystectomy

TypeinterventionalSponsorInstituto Mexicano del Seguro SocialRan2025 to 2026Enrolled40ConditionsPostoperative Pain Management, Laparoscopic Cholecystectomy, Ondansetron, Postoperative Nausea and VomitingArmsOndansetron Intraperitoneal Lavage, Saline Intraperitoneal Lavage
3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 5 syntheses or guidelines pooled it, 144 citations in OpenAlex.

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  12. Effect of supplemental oxygen 80 % on post-tonsillectomy nausea and vomiting: a randomized controlled trial.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2016
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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Dirk RüschKlinik für Anästhesie und Intensivtherapie, Universitätsklinikum Gießen und Marburg GmbH.
Leopold H J Eberhart
Jan Wallenborn
Peter Kranke
Universitätsklinikum Gießen und Marburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe German-language recommendations for the management of postoperative nausea and vomiting (PONV) have been revised by an expert committee. Major aspects of this revision are presented here in the form of an evidence-based review article.

methodsThe literature was systematically reviewed with the goal of revising the existing recommendations. New evidence-based recommendations for the management of PONV were developed, approved by consensus, and graded according to the scheme of the Scottish Intercollegiate Guidelines Network (SIGN).

resultsThe relevant risk factors for PONV include female sex, nonsmoker status, prior history of PONV, motion sickness, use of opioids during and after surgery, use of inhalational anesthetics and nitrous oxide, and the duration of anesthesia. PONV scoring systems provide a rough assessment of risk that can serve as the basis for a risk-adapted approach. Risk-adapted prophylaxis, however, has not been shown to provide any greater benefit than fixed (combination) prophylaxis, and PONV risk scores have inherent limitations; thus, fixed prophylaxis may be advantageous. Whichever of these two approaches to manage PONV is chosen, high-risk patients must be given multimodal prophylaxis, involving both the avoidance of known risk factors and the application of multiple validated and effective antiemetic interventions. PONV should be treated as soon as it arises, to minimize patient discomfort, the risk of medical complications, and the costs involved.

conclusionPONV lowers patient satisfaction but is treatable. The effective, evidence-based measures of preventing and treating it should be implemented in routine practice.

Indexed as

Evidence-Based MedicineAcupuncture TherapyAdultAlgorithmsAnalgesia, Patient-ControlledAnalgesics, OpioidAnesthesia, GeneralAntiemeticsChildChild, PreschoolCombined Modality TherapyComplementary TherapiesDrug Therapy, CombinationHumansInfantPatient SatisfactionAnalgesics, OpioidAntiemetics

Identifiers

PMID21079721
PMCPMC2977990
OpenAlexW2100643430

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.