ArticleIranian biomedical journal2010
Expression of ROR1 in patients with renal cancer--a potential diagnostic marker.
Article in Iranian biomedical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Meta-Analysis of Survival Effects of Receptor Tyrosine Kinase-like Orphan Receptor 1 (ROR1).Medicina (Kaunas, Lithuania) · 2022Pooled it
- The Role of ROR1 in Chemoresistance and EMT in Endometrial Cancer Cells.Medicina (Kaunas, Lithuania) · 2023Article
- Identification of a 12-Gene Signature and Hub Genes Involved in Kidney Wilms TumorFrontiers in oncology · 2022Article
- Targeting the Receptor Tyrosine Kinase ROR1 by Small Molecules.Handbook of experimental pharmacology · 2021Article
- Functional and clinical significance of ROR1 in lung adenocarcinoma.BMC cancer · 2020Article
- The emerging role of Wnt5a in the promotion of a pro-inflammatory and immunosuppressive tumor microenvironment.Cancer metastasis reviews · 2020Review
- ROR1 is upregulated in endometrial cancer and represents a novel therapeutic target.Scientific reports · 2020Article
- ROR1 Is Expressed in Diffuse Large B-Cell Lymphoma (DLBCL) and a Small Molecule Inhibitor of ROR1 (KAN0441571C) Induced Apoptosis of Lymphoma Cells.Biomedicines · 2020Article
- Monoclonal and Polyclonal Antibodies Specific to Human Fibromodulin.Iranian journal of biotechnology · 2019Article
- Distinct Patterns of Stromal and Tumor Expression of ROR1 and ROR2 in Histological Subtypes of Epithelial Ovarian Cancer.Translational oncology · 2017Article
- In-Silico Drug discovery approach targeting receptor tyrosine kinase-like orphan receptor 1 for cancer treatment.Scientific reports · 2017Article
- ROR1 is a novel prognostic biomarker in patients with lung adenocarcinoma.Scientific reports · 2016Article
- Receptor tyrosine kinases in carcinogenesis.Oncology letters · 2016Article
- Expression of ROR1 has prognostic significance in triple negative breast cancer.Virchows Archiv : an international journal of pathology · 2016Article
- microRNA regulation of Wnt signaling pathways in development and disease.Cellular signalling · 2015Review
- Ovarian cancer stem cells express ROR1, which can be targeted for anti-cancer-stem-cell therapy.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Progress in novel cellular therapy options for chronic lymphocytic leukemia: the M D Anderson perspective.Clinical lymphoma, myeloma & leukemia · 2014Review
- ROR1, an embryonic protein with an emerging role in cancer biology.Protein & cell · 2014Review
- Hypoxia induces phenotypic plasticity and therapy resistance in melanoma via the tyrosine kinase receptors ROR1 and ROR2.Cancer discovery · 2013Article
- Inhibition of the receptor tyrosine kinase ROR1 by anti-ROR1 monoclonal antibodies and siRNA induced apoptosis of melanoma cells.PloS one · 2013Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe ectopic expression of receptor tyrosine kinase Ror1 has been reported in patients with hematological malignancies such as chronic lymphocytic leukemia and acute lymphoblastic leukemia. Here we report, for the first time, expression of ROR1 gene in both tumor tissues and peripheral blood mononuclear cells (PBMC) from patients with renal cancer (RC).
methodsIn the current study, the expression of ROR1 gene was semi-quantitatively measured in PBMC and tumor tissues from 16 RC patients as well as PBMC from 22 healthy individuals relative to the expression of the housekeeping gene phosphoglucomutase 1 by RT-PCR.
resultsOur results showed that ROR1 was expressed at gene level in 81.3 percent of renal tumor tissues (13 out of 16) whereas it was expressed in 94 percent of PBMC from RC patients (15 out of 16). A weak expression of ROR1 was observed in PBMC of 4 out of 22 healthy individual. A significant expression of ROR1 was observed in PBMC from RC patients when compared to that in PBMC from normal healthy individuals (P less than 0.001). The expression of ROR1 in PBMC may reflect a shedding of tumor cells into blood stream.
conclusionWe conclude that detection of a high level of ROR1 expression in blood cells might assist in early detection of renal malignancies, providing taking into consideration the clinical symptoms of the disease.
Indexed as
Identifiers
21079657PMC3904057W1682502310What OpenQuestion holds
Registered trials
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