ArticleAnalytical cellular pathology (Amsterdam)2010
High frequency microsatellite instability has a prognostic value in endometrial endometrioid adenocarcinoma, but only in FIGO stage 1 cases.
Article in Analytical cellular pathology (Amsterdam), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Tools for establishing a sustainable safety culture within maternity services. A retrospective case study.SAGE open medicine · 2023Article
- Clinical impact of endometrial cancer stratified by genetic mutational profiles, POLE mutation, and microsatellite instability.PloS one · 2018Article
- Clinical course and outcome of patients with high-level microsatellite instability cancers in a real-life setting: a retrospective analysis.OncoTargets and therapy · 2017Article
- The significance of markers in the diagnosis of endometrial cancer.Przeglad menopauzalny = Menopause review · 2016Review
- Mismatch Repair Deficiency and Response to Immune Checkpoint Blockade.The oncologist · 2016Review
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10 authors.
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Abstract
objectivesto analyze the prognostic value of microsatellite instability (MSI) in a population-based study of FIGO stage 1-4 endometrial endometrioid adenocarcinomas. STUDY
designsurvival analysis in 273 patients of MSI status and clinico-pathologic features. Using a highly sensitive pentaplex polymerase chain reaction to establish MSI status, cases were divided into microsatellite stable (MSS), MSI-low (MSI-L, 1 marker positive) and MSI-high (MSI-H, 2-5 markers positive).
resultsafter 61 months median follow-up (1-209), 34 (12.5%) of the patients developed metastases but only 6.4% of the FIGO 1. MSI (especially as MSI-H vs. MSS/MSI-Lcombined) was prognostic in FIGO 1 but not in FIGO 2-4. The 5 and 10 year recurrence-free survival rates were 98% and 95% in the MSS/MSI-L vs. 85% and 73% in the MSI-H patients (p=0.005).
conclusionsMSI-H status assessed by pentaplex polymerase chain reaction is an indicator of poor prognosis in FIGO 1, but not in FIGO 2-4 endometrial endometrioid adenocarcinomas.
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