ArticleProceedings of the National Academy of Sciences of the United States of America2010
Intron retention facilitates splice variant diversity in calcium-activated big potassium channel populations.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Intron retention in health and amyotrophic lateral sclerosis.Brain : a journal of neurology · 2026Review
- Isoforms in action: The impact of transcript diversity in phenotype.Genetics and molecular biology · 2026Article
- Widespread specific intron retention events in nuclear RNA complexes identified by sedimentation analysis of pluripotent cellular extracts.Genome research · 2025Article
- RBM4-mediated intron excision of Hsf1 induces BDNF for cerebellar foliation.Communications biology · 2024Article
- RNA in axons, dendrites, synapses and beyond.Frontiers in molecular neuroscience · 2024Review
- Pan-Cancer Profiling of Intron Retention and Its Clinical Significance in Diagnosis and Prognosis.Cancers · 2023Article
- Droplet-based transcriptome profiling of individual synapses.Nature biotechnology · 2023Article
- Retained introns in long RNA-seq reads are not reliably detected in sample-matched short reads.Genome biology · 2022Article
- Article
- Review
- Two novel presentations of KCNMA1-related pathology--Expanding the clinical phenotype of a rare channelopathy.Molecular genetics & genomic medicine · 2021Article
- DHA and Its Elaborated Modulation of Antioxidant Defenses of the Brain: Implications in Aging and AD Neurodegeneration.Antioxidants (Basel, Switzerland) · 2021Review
- The changing paradigm of intron retention: regulation, ramifications and recipes.Nucleic acids research · 2019Review
- Article
- Identification and characterization of two novel alternatively spliced E2F1 transcripts in the rat CNS.Molecular and cellular neurosciences · 2018Article
- The successes and future prospects of the linear antisense RNA amplification methodology.Nature protocols · 2018Article
- Transcriptional Repression and Protein Degradation of the CaFrontiers in physiology · 2018Article
- Intron retention enhances gene regulatory complexity in vertebrates.Genome biology · 2017Article
- Intron retention as a component of regulated gene expression programs.Human genetics · 2017Review
- Integrated genome and transcriptome sequencing identifies a noncoding mutation in the genome replication factorGenome research · 2017Article
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Authors and funding
11 authors.
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Abstract
We report that the stress axis-regulated exon (STREX)-containing calcium-activated big potassium (BKCa) channel splice variant expression and physiology are regulated in part by cytoplasmic splicing and intron retention. NextGen sequencing of the mRNA complement of pooled hippocampal dendrite samples found intron 17a (i17a), the intron immediately preceding STREX, in the BKCa mRNA. Further molecular analyses of i17a revealed that the majority of i17a-containing BKCa channel mRNAs associate with STREX. i17a siRNA treatment followed by STREX protein immunocytochemistry demonstrated both reduced levels and altered subcellular distribution of STREX-containing BKCa channel protein. Selective reduction of i17a-BKCa or STREX-BKCa mRNAs induced similar changes in the burst firing properties of hippocampal neurons. Collectively, these data show that STREX splice variant regulation via cytoplasmic splicing and intron retention helps generate STREX-dependent BKCa current diversity in hippocampal neurons.
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