ArticleProceedings of the National Academy of Sciences of the United States of America2010
RNA-mediated epigenetic regulation of DNA copy number.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed.
- Genes and proteins expressed at different life cycle stages in the model protist Euplotes vannus revealed by both transcriptomic and proteomic approaches.Science China. Life sciences · 2025Article
- Programmed chromosome fragmentation in ciliated protozoa: multiple means to chromosome ends.Microbiology and molecular biology reviews : MMBR · 2023Review
- Identification of novel, functional, long noncoding RNAs involved in programmed, large-scale genome rearrangements.RNA (New York, N.Y.) · 2022Article
- The macronuclear genome of the Antarctic psychrophilic marine ciliate Euplotes focardii reveals new insights on molecular cold adaptation.Scientific reports · 2021Article
- Article
- Programmed genome rearrangements in ciliates.Cellular and molecular life sciences : CMLS · 2020Review
- Roles of Noncoding RNAs in Ciliate Genome Architecture.Journal of molecular biology · 2020Review
- Cross-Generational Effects and Non-random Developmental Response to Temperature Variation inFrontiers in cell and developmental biology · 2020Article
- Review
- Programmed Chromosome Deletion in the CiliateG3 (Bethesda, Md.) · 2019Article
- Evolutionary origins and impacts of genome architecture in ciliates.Annals of the New York Academy of Sciences · 2019Review
- 27nt-RNAs guide histone variant deposition via 'RNA-induced DNA replication interference' and thus transmit parental genome partitioning in Stylonychia.Epigenetics & chromatin · 2018Article
- Small RNA-mediated regulation of DNA dosage in the ciliateRNA (New York, N.Y.) · 2018Article
- Insights into transgenerational epigenetics from studies of ciliates.European journal of protistology · 2017Review
- Thousands of RNA-cached copies of whole chromosomes are present in the ciliateRNA (New York, N.Y.) · 2017Article
- Chromosome fusions triggered by noncoding RNA.RNA biology · 2017Article
- Putative RNA-directed adaptive mutations in cancer evolution.Transcription · 2016Article
- RNA-template dependent de novo telomere addition.RNA biology · 2016Article
- Nuclear Noncoding RNAs and Genome Stability.Molecular cell · 2016Review
- What Is a Genome?PLoS genetics · 2016Review
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5 authors.
Funding
Abstract
Increasing evidence suggests that parentally supplied RNA plays crucial roles during eukaryotic development. This epigenetic contribution may regulate gene expression from the earliest stages. Although present in a variety of eukaryotes, maternally inherited characters are especially prominent in ciliated protozoa, in which parental noncoding RNA molecules instruct whole-genome reorganization. This includes removal of nearly all noncoding DNA and sorting the remaining fragments, producing extremely gene-rich somatic genomes. Chromosome fragmentation and extensive replication produce variable DNA copy numbers in the somatic genome. Understanding the forces that drive and regulate copy number change is fundamental. We show that RNA molecules present in parental cells during sexual reproduction can regulate chromosome copy number in the developing nucleus of the ciliate Oxytricha. Experimentally induced changes in RNA abundance can both increase and decrease the levels of corresponding DNA molecules in progeny, demonstrating epigenetic inheritance of chromosome copy number. These results suggest that maternal RNA, in addition to controlling gene expression or DNA processing, can also program DNA amplification levels.
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