ArticleAntimicrobial agents and chemotherapy2011
Pharmacodynamic modeling of in vitro activity of marbofloxacin against Escherichia coli strains.
Article in Antimicrobial agents and chemotherapy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Model-based translation of results from in vitro to in vivo experiments for afabicin activity against Staphylococcus aureus.The Journal of antimicrobial chemotherapy · 2024Article
- Effects of Growth Medium and Inoculum Size on Pharmacodynamics Activity of Marbofloxacin againstAntibiotics (Basel, Switzerland) · 2021Article
- Modeling the Growth and Death ofAntibiotics (Basel, Switzerland) · 2021Article
- Pharmacokinetics/Pharmacodynamics models of veterinary antimicrobial agents.Journal of veterinary science · 2019Review
- PK-PD Integration Modeling and Cutoff Value of Florfenicol againstFrontiers in pharmacology · 2018Article
- Evaluation of Marbofloxacin in Beagle Dogs After Oral Dosing: Preclinical Safety Evaluation and Comparative Pharmacokinetics of Two Different Tablets.Frontiers in pharmacology · 2018Article
- Pharmacokinetic and Pharmacodynamic Evaluation of Marbofloxacin and PK/PD Modeling againstFrontiers in pharmacology · 2017Article
- Modeling the growth dynamics of multiple Escherichia coli strains in the pig intestine following intramuscular ampicillin treatment.BMC microbiology · 2016Article
- Pharmacodynamic modelling of in vitro activity of tetracycline against a representative, naturally occurring population of porcine Escherichia coli.Acta veterinaria Scandinavica · 2015Article
- Pharmacokinetic-pharmacodynamic model to evaluate intramuscular tetracycline treatment protocols to prevent antimicrobial resistance in pigs.Antimicrobial agents and chemotherapy · 2015Article
- Estimation of transmission parameters of a fluoroquinolone-resistant Escherichia coli strain between pigs in experimental conditions.Veterinary research · 2011Article
Corrections and comments
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Authors and funding
4 authors.
Funding
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Abstract
A mathematical pharmacodynamic model was developed to describe the bactericidal activity of marbofloxacin against Escherichia coli strains with reduced susceptibility levels (determined using MICs) under optimal and intestinal growth conditions. Model parameters were estimated using nonlinear least-square curve-fitting procedures for each E. coli strain. Parameters related to bactericidal activity were subsequently analyzed using a maximum-effect (E(max)) model adapted to account for a direct and a delayed effect. While net growth rates did not vary significantly with strain susceptibility, culture medium had a major effect. The bactericidal activity of marbofloxacin was closely associated with the concentration and the duration of exposure of the bacteria to the antimicrobial agent. The value of the concentration inducing a half-maximum effect (C(50)) was highly correlated with MIC values (R(2) = 0.87 and R(2) = 0.94 under intestinal and optimal conditions, respectively). Our model reproduced the time-kill kinetics with good accuracy (R(2) of >0.90) and helped explain observed regrowth.
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