ArticleInfection and immunity2011
Characterization of avian γδ T-cell subsets after Salmonella enterica serovar Typhimurium infection of chicks.
Article in Infection and immunity, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 72 citations in OpenAlex.
- Hens and roosters of two distinct lines differ in immune cell profiles.Poultry science · 2026Article
- Compensatory mechanisms in γδ T cell-deficient chickens followingFrontiers in immunology · 2025Article
- Dynamic Changes in the Intraepithelial Lymphocyte Numbers FollowingAnimals : an open access journal from MDPI · 2024Article
- Natural intraepithelial lymphocyte populations rise during necrotic enteritis in chickens.Frontiers in immunology · 2024Article
- Aerosol vaccination of chicken pullets with irradiated avian pathogenicFrontiers in immunology · 2023Article
- Erysipelothrix rhusiopathiae-specific T-cell responses after experimental infection of chickens selectively bred for high and low serum levels of mannose-binding lectin.Veterinary research · 2022Article
- Chicken-Specific Kinome Analysis of Early Host Immune Signaling Pathways in the Cecum of Newly Hatched Chickens Infected WithFrontiers in cellular and infection microbiology · 2022Article
- A detailed analysis of innate and adaptive immune responsiveness upon infection with Salmonella enterica serotype Enteritidis in young broiler chickens.Veterinary research · 2021Article
- T-Cell Cytokine Response inVaccines · 2021Article
- Cytokine production and phenotype of Histomonas meleagridis-specific T cells in the chicken.Veterinary research · 2019Article
- Early pathogenesis during infectious bursal disease in susceptible chickens is associated with changes in B cell genomic methylation and loss of genome integrity.Developmental and comparative immunology · 2017Article
- Replication of Toxoplasma gondii in chicken erythrocytes and thrombocytes compared to macrophages.Parasitology research · 2017Article
- Article
- Gene expression in the chicken caecum in response to infections with non-typhoid Salmonella.Veterinary research · 2014Review
- Salmonella Virchow Infection of the Chicken Elicits Cellular and Humoral Systemic and Mucosal Responses, but Limited Protection to Homologous or Heterologous Re-Challenge.Frontiers in veterinary science · 2014Article
- Salmonella enterica in the Chicken: How it has Helped Our Understanding of Immunology in a Non-Biomedical Model Species.Frontiers in immunology · 2014Review
- Long-term investigations on Toxoplasma gondii-infected primary chicken macrophages.Parasitology research · 2013Article
- Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Avian γδ T lymphocytes are frequently found in blood and organs and are assumed to be crucial to the immune defense against Salmonella infections of chicks. To elucidate the so-far-unknown immunological features of subpopulations of avian γδ T cells in the course of infection, day-old chicks were infected orally with Salmonella enterica serovar Typhimurium. Until 11 days after infection, the occurrence as well as transcription of the CD8 antigen and immunologically relevant protein genes of CD8α(-) and CD8α(+high) (CD8αα(+) CD8αβ(+)) γδ cells were analyzed using flow cytometry and quantitative real-time reverse transcription-PCR (RT-PCR) with blood, spleen, thymus, and cecum samples. After infection, an increased percentage of CD8α(+high) γδ T lymphocytes was found in blood, in spleen, and, with the highest values and most rapidly, in cecum. Within the CD8α(+high) subset, a significant rise in the number of CD8αα(+) cells was accompanied by enhanced CD8α antigen expression and reduced gene transcription of the CD8β chain. CD8αα(+) and CD8αβ(+) cells showed elevated transcription for Fas, Fas ligand (FasL), interleukin-2 receptor α (IL-2Rα), and gamma interferon (IFN-γ). While the highest fold changes in mRNA levels were observed in CD8αβ(+) cells, the mRNA expression rates of CD8αβ(+) cells never significantly exceeded those of the CD8αα(+) cells. In conclusion, both CD8α(+high) γδ T-cell subpopulations (CD8αα(+) and CD8αβ(+)) might be a potential source of IFN-γ in Salmonella-infected chicks. However, due to their prominent frequency in blood and organs after infection, the avian CD8αα(+) γδ T-cell subset seems to be unique and of importance in the course of Salmonella Typhimurium infection of very young chicks.
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