ArticleGenetics2011
Semele: a killer-male, rescue-female system for suppression and replacement of insect disease vector populations.
Article in Genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 63 citations in OpenAlex.
- Killer bee molecules: antimicrobial peptides as effector molecules to target sporogonic stages of Plasmodium.PLoS pathogens · 2013Trial
- Recombinant venom proteins in insect seminal fluid reduce female lifespan.Nature communications · 2025Article
- Modeling impact and cost-effectiveness of driving-Y gene drives for malaria elimination in the Democratic Republic of the Congo.Evolutionary applications · 2022Article
- A common gene drive language eases regulatory process and eco-evolutionary extensions.BMC ecology and evolution · 2021Article
- Engineered reproductively isolated species drive reversible population replacement.Nature communications · 2021Article
- Design and analysis of CRISPR-based underdominance toxin-antidote gene drives.Evolutionary applications · 2021Article
- Split versions of Cleave and Rescue selfish genetic elements for measured self limiting gene drive.PLoS genetics · 2021Article
- Adequacy and sufficiency evaluation of existing EFSA guidelines for the molecular characterisation, environmental risk assessment and post-market environmental monitoring of genetically modified insects containing engineered gene drives.EFSA journal. European Food Safety Authority · 2020Article
- Gene Drive Dynamics in Natural Populations: The Importance of Density Dependence, Space, and Sex.Annual review of ecology, evolution, and systematics · 2020Article
- Gene drive and resilience through renewal with next generationProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Population Dynamics of Underdominance Gene Drive Systems in Continuous Space.ACS synthetic biology · 2020Article
- Performance analysis of novel toxin-antidote CRISPR gene drive systems.BMC biology · 2020Article
- A toxin-antidote CRISPR gene drive system for regional population modification.Nature communications · 2020Article
- Cleave and Rescue, a novel selfish genetic element and general strategy for gene drive.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Functional analysis of the promoter of an early zygotic gene KLC2 in Aedes aegypti.Parasites & vectors · 2018Article
- Cheating evolution: engineering gene drives to manipulate the fate of wild populations.Nature reviews. Genetics · 2016Review
- Antipathogen genes and the replacement of disease-vectoring mosquito populations: a model-based evaluation.Evolutionary applications · 2014Article
- Release of genetically engineered insects: a framework to identify potential ecological effects.Ecology and evolution · 2013Review
- Genetic control of Aedes mosquitoes.Pathogens and global health · 2013Review
- A synthetic gene drive system for local, reversible modification and suppression of insect populations.Current biology : CB · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Two strategies to control mosquito-borne diseases, such as malaria and dengue fever, are reducing mosquito population sizes or replacing populations with disease-refractory varieties. We propose a genetic system, Semele, which may be used for both. Semele consists of two components: a toxin expressed in transgenic males that either kills or renders infertile wild-type female recipients and an antidote expressed in females that protects them from the effects of the toxin. An all-male release results in population suppression because wild-type females that mate with transgenic males produce no offspring. A release that includes transgenic females results in gene drive since females carrying the allele are favored at high population frequencies. We use simple population genetic models to explore the utility of the Semele system. We find that Semele can spread under a wide range of conditions, all of which require a high introduction frequency. This feature is desirable since transgenic insects released accidentally are unlikely to persist, transgenic insects released intentionally can be spatially confined, and the element can be removed from a population through sustained release of wild-type insects. We examine potential barriers to Semele gene drive and suggest molecular tools that could be used to build the Semele system.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.