ArticleThe Journal of biological chemistry2011
NFAT and IRF proteins regulate transcription of the anti-HIV gene, APOBEC3G.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 25 citations in OpenAlex.
- Antiviral Innate Immune Activation in HIV-Infected Adults Negatively Affects H1/IC31-Induced Vaccine-Specific Memory CD4+ T Cells.Clinical and vaccine immunology : CVI · 2015Trial
- B cell receptor signaling drives APOBEC3 expression via direct enhancer regulation in chronic lymphocytic leukemia B cells.Blood cancer journal · 2022Article
- Human Beta Defensin 2 Selectively Inhibits HIV-1 in Highly Permissive CCR6⁺CD4⁺ T Cells.Viruses · 2017Article
- Genome-wide association studies of immune, disease and production traits in indigenous chicken ecotypes.Genetics, selection, evolution : GSE · 2016Article
- Pandemic Influenza A (H1N1) Virus Infection Increases Apoptosis and HIV-1 Replication in HIV-1 Infected Jurkat Cells.Viruses · 2016Article
- RNA-Seq analysis of high NaCl-induced gene expression.Physiological genomics · 2015Article
- Transcriptional regulation of APOBEC3 antiviral immunity through the CBF-β/RUNX axis.Science advances · 2015Article
- Some findings of FADD knockdown in inhibition of HIV-1 replication in Jurkat cells and PBMCs.Molecular and cellular biochemistry · 2014Article
- Counter-regulation of T cell effector function by differentially activated p38.The Journal of experimental medicine · 2014Article
- Multiple APOBEC3 restriction factors for HIV-1 and one Vif to rule them all.Journal of molecular biology · 2014Review
- Follicular regulatory T cells control humoral autoimmunity via NFAT2-regulated CXCR5 expression.The Journal of experimental medicine · 2014Article
- Coherent functional modules improve transcription factor target identification, cooperativity prediction, and disease association.PLoS genetics · 2014Article
- Gene expression profiling identifies IRF4-associated molecular signatures in hematological malignancies.PloS one · 2014Article
- Lower HIV provirus levels are associated with more APOBEC3G protein in blood resting memory CD4+ T lymphocytes of controllers in vivo.PloS one · 2013Article
- Nuclear factor of activated T cells 1 (NFAT1)-induced permissive chromatin modification facilitates nuclear factor-κB (NF-κB)-mediated interleukin-9 (IL-9) transactivation.The Journal of biological chemistry · 2012Article
- Multi-scale modeling of HIV infection in vitro and APOBEC3G-based anti-retroviral therapy.PLoS computational biology · 2012Article
- APOBEC3 proteins and genomic stability: the high cost of a good defense.Cell cycle (Georgetown, Tex.) · 2012Article
- APOBEC3 versus Retroviruses, Immunity versus Invasion: Clash of the Titans.Molecular biology international · 2012Article
- Phosphorylation directly regulates the intrinsic DNA cytidine deaminase activity of activation-induced deaminase and APOBEC3G protein.The Journal of biological chemistry · 2011Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The human cytidine deaminase APOBEC3G (A3G) is an innate restriction factor that inhibits human immunodeficiency virus, type 1 (HIV-1) replication. Regulation of A3G gene expression plays an important role in this suppression. Currently, an understanding of the mechanism of this gene regulation is largely unknown. Here, we have identified and characterized a TATA-less core promoter with an NFAT/IRF-4 composite binding site that confers cell type-specific transcriptional regulation. We found that A3G expression is critically dependent on NFATc1/NFATc2 and IRF-4. When either NFATc1 or NFATc2 and IRF-4 were co-expressed, A3G promoter activity was observed in cells that normally lack A3G expression and expression was not detected in the presence of the individual factors. This induced A3G expression allowed normally permissive CEMss cells to adopt a nonpermissive state, able to resist an HIV-1Δvif challenge. This represents the first reporting of manipulating the restrictive state of a cell type via gene regulation. Identification of NFAT and IRF family members as critical regulators of A3G expression offers important insight into the transcriptional control mechanisms that regulate innate immune responses and identifies specific targets for therapeutic intervention aimed at effectively boosting our natural immunity, in the form of a host defensive factor, against HIV-1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.