Trial reportThe Journal of physiology2011
Effect of P2 receptor blockade with pyridoxine on sympathetic response to exercise pressor reflex in humans.
Trial report in The Journal of physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Sex differences in the purinergic 2 receptor-mediated blood pressure response to treadmill exercise in rats with simulated peripheral artery disease.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Article
- Sympathetic Nerve Activity and Blood Pressure Response to Exercise in Peripheral Artery Disease: From Molecular Mechanisms, Human Studies, to Intervention Strategy Development.International journal of molecular sciences · 2022Review
- The exercise pressor reflex: An update.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Review
- Thromboxane APhysiological reports · 2021Article
- TRPV1 and BDKRB2 receptor polymorphisms can influence the exercise pressor reflex.The Journal of physiology · 2018Article
- Whole body heat stress attenuates the pressure response to muscle metaboreceptor stimulation in humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Purinergic P2X Receptors and Heightened Exercise Pressor Reflex in Peripheral Artery Disease.Internal medicine review (Washington, D.C. : Online) · 2016Article
- Combined, but not individual, blockade of ASIC3, P2X, and EP4 receptors attenuates the exercise pressor reflex in rats with freely perfused hindlimb muscles.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Seasonal variation in muscle sympathetic nerve activity.Physiological reports · 2015Article
- Purinergic 2X receptors play a role in evoking the exercise pressor reflex in rats with peripheral artery insufficiency.American journal of physiology. Heart and circulatory physiology · 2014Article
- Identification of CaV channel types expressed in muscle afferent neurons.Journal of neurophysiology · 2013Article
- Effect of oxidative stress on sympathetic and renal vascular responses to ischemic exercise.Physiological reports · 2013Article
- Sources of intravascular ATP during exercise in humans: critical role for skeletal muscle perfusion.Experimental physiology · 2013Article
- In pursuit of P2X3 antagonists: novel therapeutics for chronic pain and afferent sensitization.Purinergic signalling · 2012Article
- Cardiovascular regulation by skeletal muscle reflexes in health and disease.American journal of physiology. Heart and circulatory physiology · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
During exercise, sympathetic nervous system activity increases and this contributes to an increase in blood pressure (i.e. exercise pressor reflex). Although animal studies suggest that purinergic P2 receptors on thin fibre sensory nerves are stimulated and evoke this reflex, human data are lacking. In this study, young healthy volunteers performed fatiguing isometric handgrip before and after a local infusion of pyridoxine (i.e. vitamin B(6)) into the 'isolated' circulation of the human forearm. Pyridoxine is converted into a P2-purinoceptor antagonist. Muscle sympathetic nerve activity and blood pressure responses to fatiguing handgrip and post-exercise circulatory occlusion were significantly less after pyridoxine than they were before. These effects were not observed after infusion of saline. These data suggest that P2 receptors contribute to the exercise pressor reflex in humans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.