ArticleThe Journal of physiology2011
The dynamics of single spike-evoked adenosine release in the cerebellum.
Article in The Journal of physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Extracellular ATP/adenosine dynamics in the brain and its role in health and disease.Frontiers in cell and developmental biology · 2023Review
- Purinergic signaling in the retina: From development to disease.Brain research bulletin · 2019Review
- The Purinome and the preBötzinger Complex - A Ménage of Unexplored Mechanisms That May Modulate/Shape the Hypoxic Ventilatory Response.Frontiers in cellular neuroscience · 2019Article
- Acute ethanol exposure has bidirectional actions on the endogenous neuromodulator adenosine in rat hippocampus.British journal of pharmacology · 2018Article
- Transient Adenosine Release Is Modulated by NMDA and GABAACS chemical neuroscience · 2017Article
- Multiple pathways for elevating extracellular adenosine in the rat hippocampal CA1 region characterized by adenosine sensor cells.Journal of neurochemistry · 2017Article
- Contribution of extrasynaptic N-methyl-D-aspartate and adenosine A1 receptors in the generation of dendritic glutamate-mediated plateau potentials.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Article
- Cell type-specific effects of adenosine on cortical neurons.Cerebral cortex (New York, N.Y. : 1991) · 2015Article
- Localized adenosine signaling provides fine-tuned negative feedback over a wide dynamic range of neocortical network activities.Journal of neurophysiology · 2015Article
- Mechanical stimulation evokes rapid increases in extracellular adenosine concentration in the prefrontal cortex.Journal of neurochemistry · 2014Article
- Activity-dependent adenosine release may be linked to activation of Na(+)-K(+) ATPase: an in vitro rat study.PloS one · 2014Article
- Adenosine A1 receptor activation mediates the developmental shift at layer 5 pyramidal cell synapses and is a determinant of mature synaptic strength.The Journal of physiology · 2013Article
- Sleep-wake sensitive mechanisms of adenosine release in the basal forebrain of rodents: an in vitro study.PloS one · 2013Article
- Deletion of ecto-5'-nucleotidase (CD73) reveals direct action potential-dependent adenosine release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Measurement of purine release with microelectrode biosensors.Purinergic signalling · 2012Article
- Inhibition of hippocampal synaptic activity by ATP, hypoxia or oxygen-glucose deprivation does not require CD73.PloS one · 2012Article
- Intracellular ATP influences synaptic plasticity in area CA1 of rat hippocampus via metabolism to adenosine and activity-dependent activation of adenosine A1 receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The purine adenosine is a potent neuromodulator in the brain, with roles in a number of diverse physiological and pathological processes. Modulators such as adenosine are difficult to study as once released they have a diffuse action (which can affect many neurones) and, unlike classical neurotransmitters, have no inotropic receptors. Thus rapid postsynaptic currents (PSCs) mediated by adenosine (equivalent to mPSCs) are not available for study. As a result the mechanisms and properties of adenosine release still remain relatively unclear. We have studied adenosine release evoked by stimulating the parallel fibres in the cerebellum. Using adenosine biosensors combined with deconvolution analysis and mathematical modelling, we have characterised the release dynamics and diffusion of adenosine in unprecedented detail. By partially blocking K+ channels, we were able to release adenosine in response to a single stimulus rather than a train of stimuli. This allowed reliable sub-second release of reproducible quantities of adenosine with stereotypic concentration waveforms that agreed well with predictions of a mathematical model of purine diffusion. We found no evidence for ATP release and thus suggest that adenosine is directly released in response to parallel fibre firing and does not arise from extracellular ATP metabolism. Adenosine release events showed novel short-term dynamics, including facilitated release with paired stimuli at millisecond stimulation intervals but depletion-recovery dynamics with paired stimuli delivered over minute time scales. These results demonstrate rich dynamics for adenosine release that are placed, for the first time, on a quantitative footing and show strong similarity with vesicular exocytosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.