ArticleCytokine2011
Facultative heterochromatin formation at the IL-1 beta promoter in LPS tolerance and sepsis.
Article in Cytokine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Immunomodulatory effects of ulinastatin combined with continuous blood purification in sepsis: a systematic review and meta-analysis.Frontiers in pharmacology · 2025Pooled it
- MK2/p38/p53 Suppress Basal IL-1β and Non-Canonical NF-κB Signaling in Macrophages.International journal of molecular sciences · 2026Article
- Sirtuins and Sepsis: Cross Talk between Redox and Epigenetic Pathways.Antioxidants (Basel, Switzerland) · 2021Review
- New insights into the cell- and tissue-specificity of glucocorticoid actions.Cellular & molecular immunology · 2021Review
- Sirtuins: potential therapeutic targets for regulating acute inflammatory response?Expert opinion on therapeutic targets · 2020Review
- Histone Lys demethylase KDM3C demonstrates anti-inflammatory effects by suppressing NF-κB signaling and osteoclastogenesis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Epigenetic and metabolic programming of innate immunity in sepsis.Innate immunity · 2019Review
- Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop?Metabolic brain disease · 2019Review
- Sirtuins and Immuno-Metabolism of Sepsis.International journal of molecular sciences · 2018Review
- Interleukin-1 Beta-A Friend or Foe in Malignancies?International journal of molecular sciences · 2018Review
- Sirtuin1 Targeting Reverses Innate and Adaptive Immune Tolerance in Septic Mice.Journal of immunology research · 2018Article
- Host resistance to endotoxic shock requires the neuroendocrine regulation of group 1 innate lymphoid cells.The Journal of experimental medicine · 2017Article
- The vaccinia virus K7 protein promotes histone methylation associated with heterochromatin formation.PloS one · 2017Article
- DYRK1A phoshorylates histone H3 to differentially regulate the binding of HP1 isoforms and antagonize HP1-mediated transcriptional repression.EMBO reports · 2014Article
- Innate immune programing by endotoxin and its pathological consequences.Frontiers in immunology · 2014Review
- RelB: an outlier in leukocyte biology.Journal of leukocyte biology · 2013Review
- Reprogramming of murine macrophages through TLR2 confers viral resistance via TRAF3-mediated, enhanced interferon production.PLoS pathogens · 2013Article
- Fueling the flame: bioenergy couples metabolism and inflammation.Journal of leukocyte biology · 2012Review
- Citrullination of histone H3 interferes with HP1-mediated transcriptional repression.PLoS genetics · 2012Article
- Hypercapnia induces cleavage and nuclear localization of RelB protein, giving insight into CO2 sensing and signaling.The Journal of biological chemistry · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The clinical phenotype in sepsis that is observed as LPS tolerance is determined by silencing of pro-inflammatory genes like IL-1 beta (IL-1β). This study shows that facultative heterochromatin (fHC) silences IL-1β expression during sepsis, where we find dephosphorylated histone H3 serine 10 and increased binding of heterochromatin protein-1 (HP-1) to the promoter. In both human sepsis blood leukocytes and an LPS tolerant human THP-1 cell model, we show that IκBα and v-rel reticuloendotheliosis viral oncogene homolog B (RelB) function as dominant labile mediators of fHC formation at the IL-1β promoter. Protein synthesis inhibition decreases levels of IκBα and RelB, converts silent fHC to euchromatin, and restores IL-1β transcription. We further show TLR dependent NFκB p65 and histone H3 serine 10 phosphorylation binding at the promoter. We conclude that the resolution phase of sepsis, which correlates with survival in humans, may depend on the plasticity of chromatin structure as found in fHC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.