ReviewBrain research2011
Do common variants play a role in risk for autism? Evidence and theoretical musings.
Review in Brain research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Presymptomatic Biological, Structural, and Functional Diagnostic Biomarkers of Autism Spectrum Disorder.Journal of neurochemistry · 2025Pooled it
- Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia.Molecular autism · 2017Pooled it
- DeepND: Deep multitask learning of gene risk for comorbid neurodevelopmental disorders.Patterns (New York, N.Y.) · 2022Article
- Postnatal Cytomegalovirus Infection May Increase the Susceptibility of Tuberous Sclerosis Complex to Autism Spectrum Disorders.Microbiology spectrum · 2022Article
- Three decades of ASD genetics: building a foundation for neurobiological understanding and treatment.Human molecular genetics · 2021Article
- Causal inference in genetic trio studies.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Identification of common genetic risk variants for autism spectrum disorder.Nature genetics · 2019Article
- The Drosophila GeneFrontiers in genetics · 2019Article
- The Italian autism network (ITAN): a resource for molecular genetics and biomarker investigations.BMC psychiatry · 2018Article
- [Genetic findings in autism spectrum disorders].Der Nervenarzt · 2017Review
- Dopaminergic variants in siblings at high risk for autism: Associations with initiating joint attention.Autism research : official journal of the International Society for Autism Research · 2016Article
- Recent advances in the genetics of autism spectrum disorder.Current neurology and neuroscience reports · 2015Review
- A genome-wide association study of autism using the Simons Simplex Collection: Does reducing phenotypic heterogeneity in autism increase genetic homogeneity?Biological psychiatry · 2015Article
- Autism spectrum disorders: from genes to neurobiology.Current opinion in neurobiology · 2015Review
- Genetic diagnosis of autism spectrum disorders: the opportunity and challenge in the genomics era.Critical reviews in clinical laboratory sciences · 2014Review
- Autism spectrum disorder: underlying neurobiology.Journal of neural transmission (Vienna, Austria : 1996) · 2014Article
- Recent challenges to the psychiatric diagnostic nosology: a focus on the genetics and genomics of neurodevelopmental disorders.International journal of epidemiology · 2014Review
- Using genetic findings in autism for the development of new pharmaceutical compounds.Psychopharmacology · 2014Review
- Variability in the common genetic architecture of social-communication spectrum phenotypes during childhood and adolescence.Molecular autism · 2014Article
- A de novo convergence of autism genetics and molecular neuroscience.Trends in neurosciences · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Both rare and common genetic variants underlie risk for almost any complex disease. Over the past few years a common tool for identifying common risk variants is genome-wide association or GWA. Our analyses focus on results from GWA targeting common variants affecting risk for autism spectrum disorders (ASD). Thus far three large GWA studies have been published, each of which highlights a single, non-overlapping risk locus. Evaluation of these studies suggests that combination of their data would diminish evidence for all of these loci, making none of them significant. Despite this paucity of findings, statistical theory can be used to infer a plausible distribution of effect sizes for SNPs affecting risk for ASD. We lay out this theory, calculate plausible distributions, and discuss the results in the context of results from GWA studies for schizophrenia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.