ArticleJournal of the American Chemical Society2010
Light-activated regulation of cofilin dynamics using a photocaged hydrogen peroxide generator.
Article in Journal of the American Chemical Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 34 citations in OpenAlex.
- Dissecting in vivo and in vitro redox responses using chemogenetics.Free radical biology & medicine · 2021Review
- A Photoactivatable Formaldehyde Donor with Fluorescence Monitoring Reveals Threshold To Arrest Cell Migration.Journal of the American Chemical Society · 2020Article
- A volumetric three-dimensional digital light photoactivatable dye display.Nature communications · 2017Article
- Subcellular Redox Targeting: Bridging in Vitro and in Vivo Chemical Biology.ACS chemical biology · 2017Review
- Interpreting Heterogeneity in Response of Cells Expressing a Fluorescent Hydrogen Peroxide Biosensor.Biophysical journal · 2015Article
- Insights into electron leakage in the reaction cycle of cytochrome P450 BM3 revealed by kinetic modeling and mutagenesis.Protein science : a publication of the Protein Society · 2015Article
- A Small-Molecule Photoactivatable Optical Sensor of Transmembrane Potential.Journal of the American Chemical Society · 2015Article
- Quantifying intracellular hydrogen peroxide perturbations in terms of concentration.Redox biology · 2014Article
- Article
- Selective uncoupling of individual mitochondria within a cell using a mitochondria-targeted photoactivated protonophore.Journal of the American Chemical Society · 2012Article
- Chemistry and biology of reactive oxygen species in signaling or stress responses.Nature chemical biology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Hydrogen peroxide (H2O2) can exert diverse signaling and stress responses within living systems depending on its spatial and temporal dynamics. Here we report a new small-molecule probe for producing H2O2 on demand upon photoactivation and its application for optical regulation of cofilin-actin rod formation in living cells. This chemical method offers many potential opportunities for dissecting biological roles for H2O2 as well as remote control of cell behavior via H2O2-mediated pathways.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.