Evidence map›Paper›PMID 21076895›Full record

ReviewCurrent diabetes reports2011

Cardiovascular disease in chronic kidney disease: data from the Kidney Early Evaluation Program (KEEP).

Peter A McCullough, Susan Steigerwalt, Kirit Tolia, Shu-Cheng Chen, Suying Li, Keith C Norris, Adam Whaley-Connell, KEEP Investigators

Abstract readReview
In one paragraph

Review in Current diabetes reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 50 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Observational
  5. Review
  6. Vitamin D and cardiovascular disease in chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2019
    Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Cardiorenal Syndrome and the Role of the Bone-Mineral Axis and Anemia.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2015
    Review
  15. Article
  16. The relationship between IL-10 levels and cardiovascular events in patients with CKD.Clinical journal of the American Society of Nephrology : CJASN · 2014
    Observational
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Peter A McCulloughDepartment of Medicine, Sections of Cardiology, Nephrology, and Endocrinology, St. John Providence Health System, Providence Park Hospital, Novi, MI, USA. peteramccullough@gmail.com
Susan Steigerwalt
Kirit Tolia
Shu-Cheng Chen
Suying Li
Keith C Norris
Adam Whaley-Connell
KEEP Investigators
Ascension · USCharles R. Drew University of Medicine and Science · USUniversity of Missouri · US

Funding

TRAINING COREP20MD000182 · NIMHD · CHARLES R. DREW UNIVERSITY OF MED &SCI · PI CUNNINGHAM, WILLIAM EMERY, SHAPIRO, MARTIN F. · 2002 to 2016
$16.5M
VITAMIN D STIMULATES CARDIAC DIFFERENTIATIONU54RR026138 · NCRR · CHARLES R. DREW UNIVERSITY OF MED & SCI · PI NORRIS, KEITH C · 2009 to 2011
$14.0M
NCRR NIH HHS U54 RR026138NIMHD NIH HHS P20 MD000182
6 · The paper itself

Abstract

Diabetes mellitus (DM) and hypertension (HTN) are leading joint risk factors for both cardiovascular disease (CVD) and chronic kidney disease (CKD). In the nationwide KEEP (Kidney Early Evaluation Program) an estimated glomerular filtration rate less than 60 mL/min/1.73 m(2) or a urine albumin:creatinine ratio ≥30 mg/g (3.4 mg/mmol) defines CKD. Overall in KEEP, the rates of identified CKD and self-reported CVD are 25.7% and 22.1%, respectively. The presence of CKD has been associated with younger ages of self-reported myocardial infarction and stroke. The combination of CVD and CKD in KEEP has been associated with shorter survival time. Finally, the presence of CVD or a prior history of coronary revascularization has been associated with modestly better rates of CVD risk factor control; however, the majority of patients with CKD have suboptimally controlled blood pressure, glucose, or lipids. These data suggest that patients with CKD are not only at higher risk for CVD and subsequent mortality, but are also ideal for targeted community--and practice-based interventions to improve risk factor control and, hopefully, reduce rates of subsequent cardiovacular events.

Indexed as

Cardiovascular DiseasesHumansKidney Failure, ChronicRisk Factors

Identifiers

PMID21076895
PMCPMC3206095
OpenAlexW2169101647

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.