ArticleNeurochemical research2011
Effects of Melissa officinalis L. (lemon balm) extract on neurogenesis associated with serum corticosterone and GABA in the mouse dentate gyrus.
Article in Neurochemical research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Pooled it
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- The Potential of Selected Plants and Their Biologically Active Molecules in the Treatment of Depression and Anxiety Disorders.International journal of molecular sciences · 2025Review
- The possible "calming effect" of subchronic supplementation of a standardised phospholipid carrier-basedFrontiers in pharmacology · 2023Article
- Dietary Euterpe oleracea Mart. attenuates seizures and damage to lipids in the brain of Colossoma macropomum.Fish physiology and biochemistry · 2021Article
- Sleep Promoting Effects of IQP-AO-101: A Double-Blind, Randomized, Placebo-Controlled Exploratory Trial.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Extraction, purification and anti-fatigue activity of γ-aminobutyric acid from mulberry (Morus alba L.) leaves.Scientific reports · 2016Article
- Effect of Melissa officinalis Capsule on the Intensity of Premenstrual Syndrome Symptoms in High School Girl Students.Nursing and midwifery studies · 2015Article
- Phytochemicals that regulate neurodegenerative disease by targeting neurotrophins: a comprehensive review.BioMed research international · 2015Review
- Herbal Insomnia Medications that Target GABAergic Systems: A Review of the Psychopharmacological Evidence.Current neuropharmacology · 2014Article
- Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence.CNS drugs · 2013Review
- Melissa officinalis and Passiflora caerulea infusion as physiological stress decreaser.International journal of clinical and experimental medicine · 2013Article
- Neuroprotective properties of Melissa officinalis after hypoxic-ischemic injury both in vitro and in vivo.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2012Article
- Coadministration of Dexamethasone andCell journalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lemon balm, leaves of Melissa officinalis L., has been used for anti-anxiety and spasmolytics. We observed the extract of Melissa officinalis L. (MOE) on cell proliferation and neuroblast differentiation in the hippocampal dentate gyrus (DG) of middle-aged mice (12 months of age) using Ki67 and doublecortin (DCX), respectively. We also observed changes in corticosterone, GAD67 and GABA-transaminase (GABA-T) to check their possible mechanisms related to neurogenesis. We administered 50 or 200 mg/kg MOE to the animals once a day for 3 weeks. For labeling of newly generated cells, we also administered 5-bromodeoxyuridine (BrdU) twice a day for 3 days from the day of the first MOE treatment. Administration of 50 or 200 mg/kg MOE dose-dependently increased Ki67 positive nuclei to 244.1 and 763.9% of the vehicle-treated group, respectively. In addition, 50 or 200 mg/kg MOE significantly increased DCX positive neuroblasts with well-developed (tertiary) dendrites. Furthermore, MOE administration significantly increased BrdU/calbindin D-28 k double labeled cells (integrated neurons into granule cells in the DG) to 245.2% of the vehicle-treated group. On the other hand, administration of MOE reduced corticosterone levels in serum and decreased GABA-T levels in the DG homogenates. These results suggest that MOE increases cell proliferation, neuroblast differentiation and integration into granule cells by decreasing serum corticosterone levels as well as by increasing GABA levels in the mouse DG.
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Registered trials
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