Evidence map›Paper›PMID 21076852›Full record

ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2011

The role of nitric oxide during healing of trauma to the skeletal muscle.

Lidiane Isabel Filippin, María José Cuevas, Elena Lima, Norma Possa Marroni, Javier Gonzalez-Gallego, Ricardo Machado Xavier

RetractedAbstract readRetracted Publication
PubMed Publisher
In one paragraph

Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Trial
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  10. Effects of nitric oxide on notexin-induced muscle inflammatory responses.International journal of biological sciences · 2015
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Lidiane Isabel FilippinServiço de Reumatologia, Laboratory of Molecular Biology of Autoimmune and Infectious Disease, Hospital de Clínicas de Porto Alegre (HCPA), Universidade Federal do Rio Grande do Sul (UFRGS), Rua Ramiro Barcelos 2350, 6º andar/sala645, Porto Alegre, RS, 90035-003, Brazil.
María José Cuevas
Elena Lima
Norma Possa Marroni
Javier Gonzalez-Gallego
Ricardo Machado Xavier

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe role of NO in muscle injury is not clear.

methodsWe examined the involvement of the NO system in the development of muscle damage in an experimental model of crush injury. The animals were divided into four groups: (1) control (CO), (2) sham trauma, (3) trauma, (4) trauma + L -NAME, in two experimental phases, 24 h and 7 days after injury.

resultsTwenty-four hours post-trauma, the crushed muscle was characterized by an intense inflammatory reaction. These changes were accompanied by increased oxidative damage, increased cytokine mRNA transcription, NF-κB binding ability and TGF-β growth factor expression in the gastrocnemius muscle. Treatment with L: -NAME markedly decreased these histological and molecular abnormalities at 24 h. However, at 7 days post-trauma, increased collagen formation was observed in the L: -NAME group. DISCUSSION: These findings indicate that NO is involved in the balance between fibrosis and healing with regeneration.

Indexed as

AnimalsCytokinesFibrosisMaleMuscle, SkeletalNitric OxideNitric Oxide Synthase Type IIOxidative StressRatsRats, WistarRegenerationWound HealingCytokinesNitric OxideNitric Oxide Synthase Type II

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.