ArticleJournal of mathematical biology2011
Selective sweeps for recessive alleles and for other modes of dominance.
Article in Journal of mathematical biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Article
- Time to fixation in changing environments.Genetics · 2021Article
- Article
- Polygenic adaptation: a unifying framework to understand positive selection.Nature reviews. Genetics · 2020Review
- How Good Are Predictions of the Effects of Selective Sweeps on Levels of Neutral Diversity?Genetics · 2020Article
- Article
- Selective Sweeps Under Dominance and Inbreeding.G3 (Bethesda, Md.) · 2020Article
- Limits to Adaptation in Partially Selfing Species.Genetics · 2016Article
- Selective Strolls: Fixation and Extinction in Diploids Are Slower for Weakly Selected Mutations Than for Neutral Ones.Genetics · 2015Article
- A Coalescent Model for a Sweep of a Unique Standing Variant.Genetics · 2015Article
- Hitchhiking of deleterious alleles and the cost of adaptation in partially selfing species.Genetics · 2014Article
- Article
- Article
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4 authors.
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Abstract
A selective sweep describes the reduction of linked genetic variation due to strong positive selection. If s is the fitness advantage of a homozygote for the beneficial allele and h its dominance coefficient, it is usually assumed that h=1/2, i.e. the beneficial allele is co-dominant. We complement existing theory for selective sweeps by assuming that h is any value in [0, 1]. We show that genetic diversity patterns under selective sweeps with strength s and dominance 0 < h < 1 are similar to co-dominant sweeps with selection strength 2hs. Moreover, we focus on the case h=0 of a completely recessive beneficial allele. We find that the length of the sweep, i.e. the time from occurrence until fixation of the beneficial allele, is of the order of √(N/s) generations, if N is the population size. Simulations as well as our results show that genetic diversity patterns in the recessive case h=0 greatly differ from all other cases.
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