ReviewAsian journal of andrology2011
The epididymis, cytoplasmic droplets and male fertility.
Review in Asian journal of andrology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed, 188 citations in OpenAlex.
- The Association Between the Progressive Motility of Bovine Spermatozoa and the Developmental Morphokinetics of In Vitro-Derived Embryos.Journal of developmental biology · 2026Article
- Epididymal extracellular vesicles harbor and convey mRNA to sperm for transfer to zygotes.Nucleic acids research · 2026Article
- Green synthesized selenium nanoparticles mitigate cyclophosphamide-induced reproductive toxicity in male Wistar rats.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Biogenesis and migration of the sperm cytoplasmic droplet require ARRDC5 and TEX38.Cell reports · 2026Article
- Sixty-day oral antioxidant supplementation enhances sperm morphology and seminal plasma antioxidant capacity in stallions.Journal of animal science · 2026Article
- Assessment of testicular echotexture in young boars and its correlation with future semen production.Frontiers in veterinary science · 2026Article
- Extracellular Vesicles, Nutrient Balance, and Redox Metabolism During Epididymal Sperm Maturation: A Perspective on the Complexity of Intercellular Interplay.Advances in anatomy, embryology, and cell biology · 2026Review
- Sperm Quality and Welfare of Sexually Mature Boars Supplemented with Partially Fermentable Insoluble Fiber.Life (Basel, Switzerland) · 2025Article
- Beneficial Effects of Resveratrol on Testicular Functions: Focus on Its Antioxidant Properties.Cells · 2025Review
- Temperatures Lower than Preferred Ones Maintain DNA Integrity and Sperm Quality ofAnimals : an open access journal from MDPI · 2025Article
- Multi-Omics Sequencing Dissects the Atlas of Seminal Plasma Exosomes from Semen Containing Low or High Rates of Sperm with Cytoplasmic Droplets.International journal of molecular sciences · 2025Article
- Basal and Immune Cells of the Epididymis: An Electron Microscopy View of Their Association.Advances in experimental medicine and biology · 2025Review
- Bull Sperm Abnormalities in Practice.Advances in anatomy, embryology, and cell biology · 2025Review
- A Mouse Model to Investigate the Impact of Gender Affirming Hormone Therapy with Estradiol on Reproduction.Advanced biology · 2024Article
- Renaissance in sperm cytoplasmic contribution to infertility.Journal of assisted reproduction and genetics · 2024Article
- CatSper Calcium Channels: 20 Years On.Physiology (Bethesda, Md.) · 2023Review
- Seasonal Variations in Semen Quality, Testosterone Levels, and Scrotal Size following Dietary Flaxseed Oil and Ascorbic Acid in South African Indigenous Rams.Animals : an open access journal from MDPI · 2023Article
- TSKS localizes to nuage in spermatids and regulates cytoplasmic elimination during spermiation.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- The association of ODF4 with AK1 and AK2 in mice is essential for fertility through its contribution to flagellar shape.Scientific reports · 2023Article
- Oxidative Stress in Assisted Reproductive Techniques, with a Focus on an Underestimated Risk Factor.Current issues in molecular biology · 2023Review
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The potential of spermatozoa to become motile during post-testicular maturation, and the relationship between the cytoplasmic droplet and fertilizing capacity are reviewed. Post-testicular maturation of spermatozoa involves the autonomous induction of motility, which can occur in vivo in testes with occluded excurrent ducts and in vitro in testicular explants, and artefactual changes in morphology that appear to occur in the testis in vitro. Both modifications may reflect time-dependent oxidation of disulphide bonds of head and tail proteins. Regulatory volume decrease (RVD), which counters sperm swelling at ejaculation, is discussed in relation to loss of cytoplasmic droplets and consequences for fertility. It is postulated that: (i) fertile males possess spermatozoa with sufficient osmolytes to drive RVD at ejaculation, permitting the droplet to round up and pinch off without membrane rupture; and (ii) infertile males possess spermatozoa with insufficient osmolytes so that RVD is inadequate, the droplet swells and the resulting flagellar angulation prevents droplet loss. Droplet retention at ejaculation is a harbinger of infertility caused by failure of the spermatozoon to negotiate the uterotubal junction or mucous and reach the egg. In this hypothesis, the epididymis regulates fertility indirectly by the extent of osmolyte provision to spermatozoa, which influences RVD and therefore droplet loss. Man is an exception, because ejaculated human spermatozoa retain their droplets. This may reflect their short midpiece, approximating head length, permitting a swollen droplet to extend along the entire midpiece; this not only obviates droplet migration and flagellar angulation but also hampers droplet loss.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.